A Retrospective Study of Clinical Effects of Powdered Caffeine Exposures Reported to Three US Poison Control Centers

被引：8

作者：

Beauchamp G.A. ^{[1
,2
]}

Johnson A.R. ^{[3
]}

Crouch B.I. ^{[3
]}

Valento M. ^{[4
,5
]}

Horowitz B.Z. ^{[1
,2
,3
]}

Hendrickson R.G. ^{[1
,2
]}

机构：

[1] Department of Emergency Medicine, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, 97239, OR

[2] Oregon, Alaska and Guam Poison Center, Portland, OR

[3] Utah Poison Control Center, University of Utah College of Pharmacy, Salt Lake City, UT

[4] Washington Poison Center, Seattle, WA

[5] Division of Emergency Medicine, University of Washington, Seattle, WA

来源：

Journal of Medical Toxicology | 2016年 / 12卷 / 3期

关键词：

Dietary supplement; Poison center; Powdered caffeine;

D O I：

10.1007/s13181-016-0545-9

中图分类号：

学科分类号：

摘要：

Introduction: Anhydrous caffeine, often sold on the Internet as a powdered caffeine product, is sold as “pure caffeine” to be used as an additive to beverages and has also been used as an ingredient in energy supplement products. Methods: This is a retrospective multiple-poison center chart review of calls regarding powdered caffeine to poison centers covering Oregon, Alaska, Guam, Washington, and Utah between January 1, 2013 and June 30, 2015. Results: There were 40 calls to three poison centers over 30 months for powdered caffeine exposure. The majority of patients were over age 19 (52.5 %; 21/40) and male (70 %; 28/40). Sixty percent (24/40) of the patients were symptomatic but only 10 % (4/40) required admission; 52.5 % (21/40) of the patient calls were for inadvertent overdose of powdered caffeine; one patient overdosed in a self-harm attempt. Discussion: Powdered caffeine calls to three poison centers during a 30-month study period were rare, and severe caffeine toxicity due to exposure was found in few patients. The majority of symptoms were reported after an inadvertent powdered caffeine overdose. Conclusions: An analysis of calls to three poison centers for powdered caffeine found that exposures were uncommon, but did result in toxicity, and highlighted that the lack of clear dosing instructions on product packaging may place patients at risk of inadvertent overdose. © 2016, American College of Medical Toxicology.

引用

页码：295 / 300

页数：5

共 45 条

[1]

Ali F., Rehman H., Stapleton D., Joshi D.D., Energy drinks and their adverse health effects: a systematic review of the current evidence, Postgrad Med, 127, 3, pp. 308-322, (2015)

[2]

Kamimori G.H., Penetar D.M., Headley D.B., Thorne D.R., Otterstetter R., Belenky G., Effect of three caffeine doses on plasma catecholamines and alertness during prolonged wakefulness, Eur J Clin Pharmacol, 56, pp. 537-544, (2000)

[3]

Seidl R., Peyrl A., Nicham R., Hauser E., A taurine and caffeine-containing drink stimulates cognitive performance and well-being, Amino Acids, 19, pp. 635-642, (2000)

[4]

Bruce C.R., Anderson M.E., Fraser S.F., Stepto N.K., Klein R., Hopkins W.G., Et al., Enhancement of 2000-m rowing performance after caffeine ingestion, Med Sci Sports Exerc, 32, pp. 1958-1963, (2000)

[5]

Juhn M., Popular sports supplements and ergogenic acids, Sports Med, 33, pp. 921-939, (2003)

[6]

Berger A.J., Alfoerd K., Cardiac arrest in a young man following excess consumption of caffeinated “energy drinks, Med J Aust, 190, pp. 41-43, (2009)

[7]

Wilson R.E., Kado H.S., Samson R., Miller A.B., A case of caffeine-induced coronary vasospasm of a 17-year-old male, Cardiovasc Toxicol, 12, pp. 175-179, (2012)

[8]

Rottlaender D., Motloch L.J., Reda S., Larbig R., Hoppe U.C., Cardiac arrest due to long QT syndrome associated with excessive consumption of energy drinks, Int J Cardiol, 158, pp. e51-e52, (2012)

[9]

Heckman M.A., Sherry K., de Mejia E.G., Energy drinks: an assessment of their market size, consumer demographics, ingredient profile, functionality, and regulations in the United States, Compr Rev Food Sci Food Saf, 9, pp. 303-317, (2010)

[10]

Seifert S.M., Schaechter J.L., Hershorin E.R., Lipshultz S.E., Health effects of energy drinks on children, adolescents, and young adults, Pediatrics, 127, pp. 511-528, (2011)

← 1 2 3 4 5 →