Skeletal muscle alterations in HFrEF vs. HFpEF

被引：43
作者：
Adams V. [1 ]
Linke A. [1 ]
Winzer E. [1 ]
机构：
[1] Clinic of Cardiology, Heart Center Leipzig, Strümpellstrasse 39, Leipzig
来源：
Current Heart Failure Reports | 2017年 / 14卷 / 6期
关键词：
Heart failure; Heart failure with preserved ejection fraction; Heart failure with reduced ejection fraction; Skeletal muscle;
D O I：
10.1007/s11897-017-0361-9
中图分类号：
学科分类号：
摘要：
Purpose of review: Severe exercise intolerance and early fatigue are hallmarks of heart failure patients either with a reduced (HFrEF) or a still preserved (HFpEF) ejection fraction. This review, therefore, will provide a contemporary summary of the alterations currently known to occur in the skeletal muscles of both HFrEF and HFpEF, and provide some further directions that will be required if we want to improve our current understanding of this area. Recent findings: Skeletal muscle alterations are well documented for over 20 years in HFrEF, and during the recent years also data are presented that in HFpEF muscular alterations are present. Alterations are ranging from a shift in fiber type and capillarization to an induction of atrophy and modulation of mitochondrial energy supply. In general, the molecular alterations are more severe in the skeletal muscle of HFrEF when compared to HFpEF. Summary: The alterations occurring in the skeletal muscle at the molecular level may contribute to exercise intolerance in HFrEF and HFpEF. Nevertheless, the knowledge of changes in the skeletal muscle of HFpEF is still sparsely available and more studies in this HF cohort are clearly warranted. © 2017, Springer Science+Business Media, LLC.
引用
收藏
页码：489 / 497
页数：8
相关论文
共 104 条
[71]  
Hirai D.M., Musch T.I., Poole D.C., Exercise training in chronic heart failure: improving skeletal muscle O2 transport and utilization, Am J Physiol Heart Circ Physiol, 309, pp. H1419-H1439, (2015)
[72]  
Howell S., Maarek J.M., Fournier M., Sullivan K., Zhan W.Z., Sieck G.C., Congestive heart failure: differential adaptation of the diaphragm and latissimus dorsi, J Appl Physiol, 79, pp. 389-397, (1995)
[73]  
Kitzman D.W., Nicklas B., Kraus W.E., Lyles M.F., Eggebeen J., Morgan T.M., Et al., Skeletal muscle abnormalities and exercise intolerance in older patients with heart failure and preserved ejection fraction, Am J Physiol Heart Circ Physiol, 306, pp. H1364-H1370, (2014)
[74]  
Tikunov B., Levine S., Mancini D., Chronic congestive heart failure elicts adaptations of endurance exercise in diaphragmatic muscle, Circulation, 95, pp. 910-916, (1997)
[75]  
Wang Y., Pessin J.E., Mechanisms for fiber-type specificity of skeletal muscle atrophy, Curr Opin Clin Nutr Metab Care, 16, pp. 243-250, (2013)
[76]  
Wing S.S., Lecker S.H., Jagoe R.T., Proteolysis in illness-associated skeletal muscle atrophy: from pathways to networks, Crit Rev Clin Lab Sci, 48, pp. 49-70, (2011)
[77]  
Rabinovich R.A., Vilaro J., Structural and functional changes of peripheral muscles in chronic obstructive pulmonary disease patients, Curr Opin Pulm Med, 16, pp. 123-133, (2010)
[78]  
Ushmorov A., Hack V., Droge W., Differential reconstitution of mitochondrial respiratory chain activity and plasma redox state by cysteine and ornithine in a model of cancer cachexia, Cancer Res, 59, pp. 3527-3534, (1999)
[79]  
De Sousa E., Veksler V., Bigard X., Mateo P., Ventura-Clapier R., Heart failure affects mitochondrial but not myofibrillar intrinsic properties of skeletal muscle, Ciculation, 102, pp. 1847-1853, (2000)
[80]  
Mettauer B., Zoll J., Sanchez H., Lampert E., Ribera F., Veksler V., Et al., Oxidative capacity of skeletal muscle in heart failure patients versus sedentary or active control subjects, JACC, 4, pp. 947-954, (2001)
234567891011