Cell adhesion molecule (NCAM): Its role in the development and functioning of cultured hippocampal neurons

被引：0
作者：
G. G. Skibo
D. A. Rusakov
I. M. Krivko
I. R. Nikonenko
A. V. Bulavka
机构：
[1] National Academy of Sciences of Ukraine,Bogomolets Institute of Physiology
[2] Dnepropetrovsk State University,undefined
来源：
Neurophysiology | 1999年 / 31卷
关键词：
Synaptic Plasticity; Growth Cone; Passive Avoidance; Neural Cell Adhesion Molecule; Neuronal Somata;
D O I：
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学科分类号：
摘要：
The dynamics of NCAM expression on the neuronal membranes in dissociated rat hippocampal cell culture during 1–12 days ofin vitro development were studied. Using immunocytochemistry and electron microscopy, quantitative estimation of NCAM re-distribution on the plasma membrane of the neurons in the course of their development and maturation was carried out. By means of computer simulation, localization of NCAM molecules on the membrane of cultured neurons was modeled. It was shown that changes in the level and pattern of NCAM expression are one of the possible mechanisms providing synaptic plasticity and learning and memory processes.
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页码：199 / 202
页数：3
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