The Role of Statins in Cirrhosis

[1] Mallat A(1994)Effect of simvastatin, an inhibitor of hydroxy-methylglutaryl coenzyme A reductase, on the growth of human Ito cells Hepatology 20 1589-1594

[2] Preaux AM(2021)The search for disease-modifying agents in decompensated cirrhosis: from drug repurposing to drug discovery J Hepatol 75 S118-S134

[3] Blazejewski S(2007)Atorvastatin lowers portal pressure in cirrhotic rats by inhibition of RhoA/Rho-kinase and activation of endothelial nitric oxide synthase Hepatology 46 242-253

[4] Dhumeaux D(2010)Atorvastatin attenuates hepatic fibrosis in rats after bile duct ligation via decreased turnover of hepatic stellate cells J Hepatol 53 702-712

[5] Rosenbaum J(2000)The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals Nat Med 6 1004-1010

[6] Mavier P(2007)Simvastatin treatment improves liver sinusoidal endothelial dysfunction in CCl4 cirrhotic rats J Hepatol 46 1040-1046

[7] Caraceni P(2015)KLF2 exerts antifibrotic and vasoprotective effects in cirrhotic rat livers: behind the molecular mechanisms of statins Gut 64 1434-1443

[8] Abraldes JG(2017)Cross-talk between autophagy and KLF2 determines endothelial cell phenotype and microvascular function in acute liver injury J Hepatol 66 86-94

[9] Ginès P(2021)Portal hypertension in cirrhosis: pathophysiological mechanisms and therapy JHEP Rep 3 20183-639

[10] Newsome PN(2019)Restoration of liver sinusoidal cell phenotypes by statins improves portal hypertension and histology in rats with NASH Sci Rep 9 118293-1506

[1] Mallat A(1994)Effect of simvastatin, an inhibitor of hydroxy-methylglutaryl coenzyme A reductase, on the growth of human Ito cells Hepatology 20 1589-1594

[2] Preaux AM(2021)The search for disease-modifying agents in decompensated cirrhosis: from drug repurposing to drug discovery J Hepatol 75 S118-S134

[3] Blazejewski S(2007)Atorvastatin lowers portal pressure in cirrhotic rats by inhibition of RhoA/Rho-kinase and activation of endothelial nitric oxide synthase Hepatology 46 242-253

[4] Dhumeaux D(2010)Atorvastatin attenuates hepatic fibrosis in rats after bile duct ligation via decreased turnover of hepatic stellate cells J Hepatol 53 702-712

[5] Rosenbaum J(2000)The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals Nat Med 6 1004-1010

[6] Mavier P(2007)Simvastatin treatment improves liver sinusoidal endothelial dysfunction in CCl4 cirrhotic rats J Hepatol 46 1040-1046

[7] Caraceni P(2015)KLF2 exerts antifibrotic and vasoprotective effects in cirrhotic rat livers: behind the molecular mechanisms of statins Gut 64 1434-1443

[8] Abraldes JG(2017)Cross-talk between autophagy and KLF2 determines endothelial cell phenotype and microvascular function in acute liver injury J Hepatol 66 86-94

[9] Ginès P(2021)Portal hypertension in cirrhosis: pathophysiological mechanisms and therapy JHEP Rep 3 20183-639

[10] Newsome PN(2019)Restoration of liver sinusoidal cell phenotypes by statins improves portal hypertension and histology in rats with NASH Sci Rep 9 118293-1506