Evaluation of Hot Nodules of Thyroid Gland Using Tc-99m Pertechnetate: a Novel Approach Using Quantitative Single-Photon Emission Computed Tomography/Computed Tomography

被引：18
作者：
Lee R. [1 ]
So Y. [2 ]
Song Y.S. [1 ]
Lee W.W. [1 ,3 ]
机构：
[1] Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 82, Gumi-ro 173 Beon-gil, Bundang-gu, Seongnam-si, 13620, Gyeonggi-do
[2] Department of Nuclear Medicine, Konkuk University Medical Center, Seoul
[3] Institute of Radiation Medicine, Medical Research Center, Seoul National University, Seoul
来源：
Nuclear Medicine and Molecular Imaging | 2018年 / 52卷 / 6期
基金：
新加坡国家研究基金会;
关键词：
Computed tomography; Hot nodule; Quantitation; Single-photon emission computed tomography; Standardized uptake value; Tc-99m pertechnetate; Thyroid;
D O I：
10.1007/s13139-018-0554-5
中图分类号：
学科分类号：
摘要：
Planar scintigraphy using Tc-99m pertechnetate is useful for snapshot evaluation of hot thyroid nodules, which are pathologically follicular adenoma and seldom, if ever, malignant. The autonomy of the hot nodules has been demonstrated by the presence of thyroid-stimulating hormone-dependent extra-nodular thyroid tissue besides the hot nodules. Here, we present two cases of hot thyroid nodules in patients who underwent quantitative single-photon emission computed tomography/computed tomography (SPECT/CT). In addition to the nodules, contralateral normal thyroid parenchyma was evaluated based on standardized uptake values. One patient had a traditional follicular adenoma suppressing other thyroid tissue, whereas the other patient seemed to have a nodule erupting from underlying hyperfunctioning, not suppressed, thyroid tissue. This novel approach using quantitative SPECT/CT unveils a new pathology of hot thyroid nodule that does not suppress, but coincides with hyperfunctioning thyroid tissue. © 2018, Korean Society of Nuclear Medicine.
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收藏
页码：468 / 472
页数：4
相关论文
共 21 条
  • [1] Hegedus L., Clinical practice. The thyroid nodule, N Engl J Med, 351, pp. 1764-1771, (2004)
  • [2] Haugen B.R., Alexander E.K., Bible K.C., Doherty G.M., Mandel S.J., Nikiforov Y.E., Et al., 2015 American Thyroid Association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer, Thyroid, 26, pp. 1-133, (2016)
  • [3] Nygaard B., Hegedus L., Nielsen K.G., Ulriksen P., Hansen J.M., Long-term effect of radioactive iodine on thyroid function and size in patients with solitary autonomously functioning toxic thyroid nodules, Clin Endocrinol, 50, pp. 197-202, (1999)
  • [4] Gharib H., Papini E., Thyroid nodules: clinical importance, assessment, and treatment, Endocrinol Metab Clin N Am, 36, pp. 707-735, (2007)
  • [5] Ross D.S., Evaluation of the thyroid nodule, J Nucl Med, 32, pp. 2181-2192, (1991)
  • [6] Mazzaferri E.L., Management of a solitary thyroid nodule, N Engl J Med, 328, pp. 553-559, (1993)
  • [7] Lee W.W., Lee B., Kim S.J., Jin J., Moon D.H., Lee H., Kinetics of iodide uptake and efflux in various human thyroid cancer cells by expressing sodium iodide symporter gene via a recombinant adenovirus, Oncol Rep, 10, pp. 845-849, (2003)
  • [8] Meller J., Becker W., The continuing importance of thyroid scintigraphy in the era of high-resolution ultrasound, Eur J Nucl Med Mol Imaging, 29, pp. S425-S438, (2002)
  • [9] Shimmins J., Alexander W.D., McLarty D.G., Robertson J.W., Sloane D.J., 99mTc-pertechnetate for measuring thyroid suppressibility, J Nucl Med, 12, pp. 51-54, (1971)
  • [10] Kusic Z., Becker D.V., Saenger E.L., Paras P., Gartside P., Wessler T., Et al., Comparison of technetium-99m and iodine-123 imaging of thyroid nodules: correlation with pathologic findings, J Nucl Med, 31, pp. 393-399, (1990)
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