The Role of Metabolites of Antidepressants in the Treatment of Depression

被引：0
作者：
Matthew V. Rudorfer
William Z. Potter
机构：
[1] National Institute of Mental Health,Clinical Treatment Research Branch, Division of Clinical and Treatment Research
[2] National Institute of Mental Health,Section on Clinical Pharmacology, Experimental Therapeutics Branch
[3] Eli Lilly & Co.,undefined
来源：
CNS Drugs | 1997年 / 7卷
关键词：
Adis International Limited; Fluoxetine; Venlafaxine; Desipramine; Clomipramine;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Recognition of the role of active metabolites in mediating therapeutic and/or adverse effects of many antidepressants is an important part of understanding the mechanisms of action of these medications. While virtually all antidepressants except lithium undergo extensive hepatic metabolism, the profile of activity of the resulting breakdown products varies considerably.
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页码：273 / 312
页数：39
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  • [1] Hammer W.(1967)Plasma levels of monomethylated tricyclic antidepressants during treatment with imipramine-like compounds Life Sci 6 1895-903
  • [2] Sjöqvist F.(1982)Active metabolites of imipramine and desipramine in man Clin Pharmacol Ther 31 393-401
  • [3] Potter W.Z.(1992)Pharmacokinetic and pharmacodynamic significance of antidepressant drug metabolites Pharmacol Res 26 317-29
  • [4] Calil H.M.(1989)Antidepressants: a comparative review of the clinical pharmacology and therapeutic use of the ‘newer’ versus the ‘older’ drugs Drugs 37 713-38
  • [5] Sutfin T.(1990)Antidepressants, metabolites, and apparent drug resistance Clin Neuropharmacol 13 S45-53
  • [6] Caccia S.(1994)Comparative tolerability profiles of the newer versus older antidepressants Drug Saf 10 18-46
  • [7] Garattini S.(1991)The pharmacologic treatment of depression N Engl J Med 325 633-42
  • [8] Rudorfer M.V.(1990)Role of cytochromes P450 in drug metabolism and hepatotoxicity Semin Liver Dis 10 235-50
  • [9] Potter W.Z.(1996)Cytochrome P450 enzymes: interpretation of their interactions with selective serotonin reuptake inhibitors. Part I J Clin Psychopharmacol 16 273-85
  • [10] Potter W.Z.(1991)Cytochrome P450 monooxygenases and interactions of psychotropic drugs Int J Psychiatry Med 21 47-56
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