Co-selection for antibiotic resistance by environmental contaminants

被引：26
作者：
Laura May Murray
April Hayes
Jason Snape
Barbara Kasprzyk-Hordern
William Hugo Gaze
Aimee Kaye Murray
机构：
[1] University of Exeter Medical School,European Centre for Environment and Human Health
[2] Faculty of Health and Life Sciences,Department of Chemistry
[3] Environment and Sustainability Institute,undefined
[4] Formerly AstraZeneca Global Environment,undefined
[5] University of Bath,undefined
来源：
npj Antimicrobials and Resistance | / 2卷 / 1期
关键词：
D O I：
10.1038/s44259-024-00026-7
中图分类号：
学科分类号：
摘要：
The environment is increasingly recognised as a hotspot for the selection and dissemination of antibiotic resistant bacteria and antibiotic resistance genes. These can be selected for by antibiotics and non-antibiotic agents (such as metals and biocides), with the evidence to support this well established by observational and experimental studies. However, there is emerging evidence to suggest that plant protection products (such as herbicides), and non-antibiotic drugs (such as chemotherapeutic agents), can also co-select for antibiotic resistance. This review aims to provide an overview of four classes of non-antibiotic agents (metals, biocides, plant protection products, and non-antibiotic drugs) and how they may co-select for antibiotic resistance, with a particular focus on the environment. It also aims to identify key knowledge gaps that should be addressed in future work, to better understand these potential co-selective agents.
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