Human cytomegalovirus microRNA miR-US4-1 inhibits CD8+ T cell responses by targeting the aminopeptidase ERAP1

被引：0
|
作者：
Sungchul Kim
Sanghyun Lee
Jinwook Shin
Youngkyun Kim
Irini Evnouchidou
Donghyun Kim
Young-Kook Kim
Young-Eui Kim
Jin-Hyun Ahn
Stanley R Riddell
Efstratios Stratikos
V Narry Kim
Kwangseog Ahn
机构：
[1] National Creative Research Initiative Center for Antigen Presentation,Department of Biological Sciences
[2] Seoul National University,Department of Molecular Genetics and Microbiology
[3] Duke University Medical Center,Department of Biological Sciences
[4] Institute of Radioisotopes and Radiodiagnostic Products,Department of Molecular Cell Biology
[5] National Centre for Scientific Research Demokritos,Clinical Research Division
[6] Seoul National University,undefined
[7] Samsung Biomedical Research Institute,undefined
[8] Sungkyunkwan University School of Medicine,undefined
[9] Fred Hutchinson Cancer Research Center,undefined
来源：
Nature Immunology | 2011年 / 12卷
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学科分类号：
摘要：
Viral microRNAs can modulate a variety of host genes. Ahn and colleagues identify a human cytomegalovirus microRNA that downregulates the peptide-processing enzyme ERAP1 and prevents presentation of antigenic viral peptides.
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页码：984 / 991
页数：7
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