The CAR-HEMATOTOX score as a prognostic model of toxicity and response in patients receiving BCMA-directed CAR-T for relapsed/refractory multiple myeloma

被引：0
|
作者：
Kai Rejeski
Doris K. Hansen
Radhika Bansal
Pierre Sesques
Sikander Ailawadhi
Jennifer M. Logue
Eva Bräunlein
David M. Cordas dos Santos
Ciara L. Freeman
Melissa Alsina
Sebastian Theurich
Yucai Wang
Angela M. Krackhardt
Frederick L. Locke
Emmanuel Bachy
Michael D. Jain
Yi Lin
Marion Subklewe
机构：
[1] LMU Munich,Department of Medicine III – Hematology/Oncology, LMU University Hospital
[2] LMU Gene Center,Laboratory for Translational Cancer Immunology
[3] German Cancer Consortium (DKTK),Department of Blood and Marrow Transplant and Cellular Immunotherapy
[4] Munich Site,Division of Hematology
[5] and German Cancer Research Center,Division of Hematology and Oncology
[6] Bavarian Cancer Research Center (BZKF),IIIrd Medical Department, Klinikum rechts der Isar and Center for Translational Cancer Research (TranslaTUM), School of Medicine
[7] Moffitt Cancer Center,Department of Medicine I
[8] Mayo Clinic,undefined
[9] Hospices Civils de Lyon,undefined
[10] Université Claude Bernard Lyon 1,undefined
[11] INSERM 1052,undefined
[12] Mayo Clinic,undefined
[13] Technical University of Munich,undefined
[14] Malteser Hospital St. Franziskus Hospital,undefined
来源：
Journal of Hematology & Oncology | / 16卷
关键词：
Chimeric antigen receptor; BCMA CAR-T; Hematological toxicity; Cytopenias; Multiple myeloma; Infections;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 50 条
  • [21] Key predictors of long-term outcomes in BCMA-targeted CAR-T therapy for relapsed/refractory multiple myeloma
    Ning An
    Juan Li
    Pan Luo
    Di Wang
    Peiling Zhang
    Chang Shu
    Songbai Cai
    Qiuxia Yu
    Xinyu Wen
    Xinran Wang
    Wei Mu
    Jianlin Hu
    Chunrui Li
    Journal of Translational Medicine, 23 (1)
  • [22] Infections associated with CAR-T cell therapy in patients with relapsed refractory multiple myeloma: Risks and prevention strategies
    An, Jing
    Zhao, Jie
    Zou, Ping
    Zhang, Yicheng
    Wei, Junni
    Tian, Weiwei
    Wei, Jia
    CANCER MEDICINE, 2024, 13 (12):
  • [23] Strategies for salvage therapy post CAR-T therapy failure in refractory/relapsed multiple myeloma patients
    Min, Chao
    Zhong, Xiong
    Cui, Yue
    Zhang, Hanfu
    Wang, Qingming
    FRONTIERS IN PHARMACOLOGY, 2025, 16
  • [24] Safety and Efficacy of BCMA CAR-T Cell Therapy in Older Patients With Multiple Myeloma
    Reyes, Kevin R.
    Huang, Chiung-Yu
    Lo, Mimi
    Arora, Shagun
    Chung, Alfred
    Wong, Sandy W.
    Wolf, Jeffrey
    Olin, Rebecca L.
    Martin, Thomas
    Shah, Nina
    Banerjee, Rahul
    TRANSPLANTATION AND CELLULAR THERAPY, 2023, 29 (06): : 350 - 355
  • [25] Simple Score of Albumin and CRP Predicts High-Grade Toxicity in Patients with Multiple Myeloma Receiving CAR-T Therapy
    Akhtar, Othman S.
    Modi, Karnav
    Kim, Jongphil
    Skelson, Lawrence
    Smith, Eric
    Al-Jumayli, Mohammed A.
    Extermann, Martine
    De Avila, Gabriel
    Parker, Nathan
    Puglianini, Omar Castaneda
    Cruz, Ariel Grajales
    Baz, Rachid
    Blue, Brandon
    Shain, Kenneth
    Alsina, Melissa
    Liu, Hien
    Nishihori, Taiga
    Jain, Michael D.
    Locke, Frederick L.
    Hansen, Doris K.
    Freeman, Ciara L.
    TRANSPLANTATION AND CELLULAR THERAPY, 2024, 30 (03): : 283.e1 - 283.e10
  • [26] Lenalidomide enhances the efficacy of anti-BCMA CAR-T treatment in relapsed/refractory multiple myeloma: a case report and revies of the literature
    Zhao, Guoxing
    Wei, Runhong
    Feng, Lei
    Wu, Yi
    He, Feng
    Xiao, Mingxing
    Cheng, Zhi
    CANCER IMMUNOLOGY IMMUNOTHERAPY, 2022, 71 (01) : 39 - 44
  • [27] Cilta-cel, a BCMA-targeting CAR-T therapy for patients with multiple myeloma
    Jagannath, Sundar
    Jackson, Carolyn C.
    Schecter, Jordan M.
    Lendvai, Nikoletta
    Sun, Huabin
    Akram, Muhammad
    Patel, Nitin
    Martin, Thomas G.
    EXPERT OPINION ON BIOLOGICAL THERAPY, 2024, 24 (05) : 339 - 350
  • [28] Enhanced platelet function through CAR-T cell therapy in relapsed/refractory multiple myeloma
    Ma, Ruixue
    Zhang, Qi
    Liu, Yang
    Li, Hujun
    Chen, Huimin
    Zhang, Qianqian
    Qiao, Jianlin
    Qi, Kunming
    Shen, Guifang
    Sun, Cai
    Song, Xuguang
    Cao, Jiang
    Cheng, Hai
    Zhu, Feng
    Yan, Zhiling
    Sang, Wei
    Li, Depeng
    Sun, Haiying
    Zheng, Junnian
    Li, Zhenyu
    Xu, Kailin
    Chen, Wei
    CLINICAL AND EXPERIMENTAL MEDICINE, 2024, 24 (01)
  • [29] Identification of potential resistance mechanisms and therapeutic targets for the relapse of BCMA CAR-T therapy in relapsed/refractory multiple myeloma through single-cell sequencing
    Li, Wei
    Zhang, Binglei
    Cao, Weijie
    Zhang, Wenli
    Li, Tiandong
    Liu, Lina
    Xu, LinPing
    Gao, Fengcai
    Wang, Yanmei
    Wang, Fang
    Xing, Haizhou
    Jiang, Zhongxing
    Shi, Jianxiang
    Bian, Zhilei
    Song, Yongping
    EXPERIMENTAL HEMATOLOGY & ONCOLOGY, 2023, 12 (01)
  • [30] Identification of potential resistance mechanisms and therapeutic targets for the relapse of BCMA CAR-T therapy in relapsed/refractory multiple myeloma through single-cell sequencing
    Wei Li
    Binglei Zhang
    Weijie Cao
    Wenli Zhang
    Tiandong Li
    Lina Liu
    LinPing Xu
    Fengcai Gao
    Yanmei Wang
    Fang Wang
    Haizhou Xing
    Zhongxing Jiang
    Jianxiang Shi
    Zhilei Bian
    Yongping Song
    Experimental Hematology & Oncology, 12
12345