Analysis of histamine and modeling of ligand-receptor interactions in the histamine H1 receptor for Magic Angle Spinning NMR studies

被引：0
|
作者：
V. R. Prasad Ratnala
F. B. Hulsbbergen
H. J. M. de Groot
W. J. de Grip
机构：
[1] Leiden Institute of Chemistry,Department of Biochemistry UMC
[2] Gorlaeus Laboratoria,160
[3] Nijmegen Center of Molecular Life Sciences,undefined
[4] University Medical Center Nijmegen,undefined
来源：
Inflammation Research | 2003年 / 52卷
关键词：
Histamine H; receptors; G protein coupled receptors; MAS NMR; Ligand binding; ESTs;
D O I：
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中图分类号：
学科分类号：
摘要：
Objective and Design: Investigation of the principles of ligand-receptor interaction in histamine receptors can help to provide a solid foundation for structure-based drug design. Stable isotope labelling of the ligand 'Histamine' has been performed and 1D 13C CP MAS and 2D Radio Frequency Dipolar Recoupling (RFDR) spectra for the ligand are presented. Hyperfine signals were well spread and did not suffer from any sizable line broadening. The production of H1 receptor for Magic Angle Spinning NMR studies is currently in progress.
引用
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页码：417 / 423
页数：6
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