Diagnostic value of alternative techniques to gadolinium-based contrast agents in MR neuroimaging—a comprehensive overview

被引：0

作者：

Anna Falk Delgado

Danielle Van Westen

Markus Nilsson

Linda Knutsson

Pia C. Sundgren

Elna-Marie Larsson

Alberto Falk Delgado

机构：

[1] Karolinska Institutet,Clinical neurosciences

[2] Karolinska University Hospital,Department of Neuroradiology

[3] Lund University,Department of Clinical Sciences/Radiology, Faculty of Medicine

[4] Lund University,Department of Medical Radiation Physics

[5] Johns Hopkins University,Russell H. Morgan Department of Radiology and Radiological Science, School of Medicine

[6] University of Michigan,Department of Radiology

[7] Uppsala University,Department of Surgical Sciences, Radiology

来源：

Insights into Imaging | / 10卷

关键词：

Non-contrast-enhanced; Gadolinium; Area under curve; Diagnostic performance; Brain;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Gadolinium-based contrast agents (GBCAs) increase lesion detection and improve disease characterization for many cerebral pathologies investigated with MRI. These agents, introduced in the late 1980s, are in wide use today. However, some non-ionic linear GBCAs have been associated with the development of nephrogenic systemic fibrosis in patients with kidney failure. Gadolinium deposition has also been found in deep brain structures, although it is of unclear clinical relevance. Hence, new guidelines from the International Society for Magnetic Resonance in Medicine advocate cautious use of GBCA in clinical and research practice. Some linear GBCAs were restricted from use by the European Medicines Agency (EMA) in 2017.

引用

共 782 条

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