Diagnostic value of alternative techniques to gadolinium-based contrast agents in MR neuroimaging—a comprehensive overview

被引：0
作者：
Anna Falk Delgado
Danielle Van Westen
Markus Nilsson
Linda Knutsson
Pia C. Sundgren
Elna-Marie Larsson
Alberto Falk Delgado
机构：
[1] Karolinska Institutet,Clinical neurosciences
[2] Karolinska University Hospital,Department of Neuroradiology
[3] Lund University,Department of Clinical Sciences/Radiology, Faculty of Medicine
[4] Lund University,Department of Medical Radiation Physics
[5] Johns Hopkins University,Russell H. Morgan Department of Radiology and Radiological Science, School of Medicine
[6] University of Michigan,Department of Radiology
[7] Uppsala University,Department of Surgical Sciences, Radiology
来源：
Insights into Imaging | / 10卷
关键词：
Non-contrast-enhanced; Gadolinium; Area under curve; Diagnostic performance; Brain;
D O I：
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摘要：
Gadolinium-based contrast agents (GBCAs) increase lesion detection and improve disease characterization for many cerebral pathologies investigated with MRI. These agents, introduced in the late 1980s, are in wide use today. However, some non-ionic linear GBCAs have been associated with the development of nephrogenic systemic fibrosis in patients with kidney failure. Gadolinium deposition has also been found in deep brain structures, although it is of unclear clinical relevance. Hence, new guidelines from the International Society for Magnetic Resonance in Medicine advocate cautious use of GBCA in clinical and research practice. Some linear GBCAs were restricted from use by the European Medicines Agency (EMA) in 2017.
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