How erythrocyte volume is regulated, or what mathematical models can and cannot do for biology

被引：12
作者：
Ataullakhanov F.I. [1 ,2 ,3 ]
Korunova N.O. [2 ]
Spiridonov I.S. [2 ]
Pivovarov I.O. [3 ]
Kalyagina N.V. [4 ]
Martinov M.V. [2 ]
机构：
[1] Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences
[2] National Research Center for Hematology, Russian Academy of Medical Sciences
[3] Physics Department, Moscow Lomonosov State University
[4] Bauman State Technical University
来源：
Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology | 2009年 / 3卷 / 2期
关键词：
Ca[!sup]2+[!/sup]-activated K[!sup]+[!/sup]-channels; Cell volume; Mathematical models; Na[!sup]+[!/sup; K[!sup]+[!/sup]-pump; Red blood cell;
D O I：
10.1134/S1990747809020019
中图分类号：
学科分类号：
摘要：
Modern concepts of the red blood cell (RBC) volume regulation are considered. It is shown that the system of ion pumps and channels in the cell membrane ensures the physiological value of volume with a precision of about 10% even at 5- to 7-fold variations of passive membrane permeability for ions. Particular attention is paid to mathematical models for evaluation of the role of different molecular mechanisms in the RBC volume control. It is shown that many questions, for example, 'why the Na+,K+-ATPase pumps the ions in opposite direction' or 'what is the physiological role of Ca2+ -activated K+-channels', cannot be answered without adequate mathematical models of such complex control systems as cell volume control. © Pleiades Publishing, Ltd. 2009.
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页码：101 / 115
页数：14
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