Orbital rhabdomyosarcoma with skin metastasis: A case report

被引：4

作者：

Elomrani F. ^{[1
]}

Touri S. ^{[2
]}

Ouziane I. ^{[1
]}

Berrada N. ^{[1
]}

Boutayeb S. ^{[1
]}

Mrabti H. ^{[1
]}

Elkhannoussi B. ^{[2
]}

Errihani H. ^{[1
]}

机构：

[1] Department of Medical Oncology, National Institute of Oncology, Rabat

[2] Department of Pathology, National Institute of Oncology, Rabat

来源：

BMC Research Notes | / 7卷 / 1期

关键词：

Chemotherapy; Cutaneous metastasis; Immunohistochemistry; Radiotherapy; Rhabdomyosarcoma; Treatment;

D O I：

10.1186/1756-0500-7-670

中图分类号：

学科分类号：

摘要：

Background: Rhabdomyosarcoma is a soft tissue neoplasm that usually arises in the headand neck region and genitourinary tract. Skin metastasis of rhabdomyosarcoma is extremely rare; of thirteen cases reported in the literature, most were children younger than 10 years and only three cases have been reported in adults.; Case presentation: A 20-year-old Moroccan man was admitted with a right orbital tumor. The tumor was excised and histopathology examination confirmed a diagnosis of rhabdomyosarcoma. The patient was treated with chemotherapy, but local recurrence occurred one year later. The patient underwent right orbital exenteration followed by chemotherapy and radiotherapy. After 6 months, the patient developed a cutaneous mass in the right lumbar region, which was resected. Immunohistochemical examination of the tumor showed this to be a cutaneous metastasis of rhabdomyosarcoma. The patient was treated by chemotherapy and there appeared to be no recurrence after 9 months of follow up.; Conclusions: Skin metastasis from rhabdomyosarcoma is extremely rare, particularly in adults. The purpose of presenting this case report is to raise awareness among clinicians - skin biopsy and immunohistochemistry are needed to distinguish this neoplasm from other cutaneous tumors so that appropriate treatment can be initiated. © 2014 Elomrani et al.; licensee BioMed Central Ltd.

引用

共 22 条

[1]

Ries L.A.G., Smith M.A., Gurney J.G., Linet M., Tamra T., Young J.L., Bunin G.R., Cancer incidence and survival among children and adolescents: United States SEER Program 1975-1995, NIH Pub. No. 99-4649, (1999)

[2]

Gandhi P., Fleming J., Haik B., Wilson M., Ophthalmic complications following treatment of paranasal sinus rhabdomyosarcoma in comparison to orbital disease, Ophthal Plast Reconstr Surg, 0, pp. 1-6, (2011)

[3]

Notis C.M., Abramson D.H., Sagerman R.H., Ellsworth R.M., Orbital rhabdomyosarcoma: Treatment or overtreatment, Ophtalmic Genet, 16, 4, pp. 159-162, (1995)

[4]

Crist W., Gehan E.A., Ragab A.H., Dickman P.S., Donaldson S.S., Fryer C., Hammond D., Hays D.M., Herrmann J., Heyn R., The Third Intergroup Rhabdomyosarcoma Study, J Clin Oncol, 13, pp. 610-630, (1995)

[5]

Crist W.M., Anderson J.R., Meza J.L., Fryer C., Raney R.B., Ruymann F.B., Breneman J., Qualman S.J., Wiener E., Wharam M., Lobe T., Webber B., Maurer H.M., Donaldson S.S., Intergroup Rhabdomyosarcoma Study-IV, results for patients with nonmetastatic disease, J Clin Oncol, 19, pp. 3091-3102, (2001)

[6]

Satoko S., Chikako Y., Koichiro M., Kikuo T., Metastatic rhabdomyosarcoma of the skin, J Am Acad Dermatol, 58, pp. 118-120, (2008)

[7]

Ansai S., Takeda H., Koseki S., Hozumi Y., Kondo S., A patient with rhabdomyosarcoma and clear cell sarcoma of the skin, J Am Acad Dermatol, 31, pp. 871-876, (1994)

[8]

Simsir A., Ioffe O.B., Henry M., Adult rhabdomyosarcoma with skin metastases: Diagnosis by fine needle aspiration biopsy, Acta Cytol, 45, pp. 106-108, (2001)

[9]

Hayashi K., Ohtsuki Y., Takahashi K., Sonobe H., Nakamura S., Kitagawa N., Arata J., Shimanouchi Y., Kurashige T., Congenital alveolar rhabdomyosarcoma with multiple skin metastases: Report of a case, Acta Pathol Jpn, 38, pp. 241-248, (1988)

[10]

Kitagawa N., Arata J., Ohtsuki Y., Hayashi K., Oomori Y., Tomoda T., Congenital alveolar rhabdomyosarcoma presenting as a blueberry muffin baby, J Dermatol, 16, pp. 409-411, (1989)

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