Granisetron Adjunct to Fluvoxamine for Moderate to Severe Obsessive-Compulsive DisorderA Randomized, Double-Blind, Placebo-Controlled Trial

被引：0
作者：
Neda Askari
Mahdieh Moin
Mohammad Sanati
Masih Tajdini
Seyed-Mohammad-Reza Hosseini
Amirhossein Modabbernia
Babak Najand
Samrand Salimi
Mina Tabrizi
Mandana Ashrafi
Reza Hajiaghaee
Shahin Akhondzadeh
机构：
[1] Tehran University of Medical Sciences,Psychiatric Research Center, Roozbeh Hospital
[2] Tehran University of Medical Sciences,Baharloo Hospital
[3] Tehran University of Medical Sciences,Department of Medical Genetics, Faculty of Medicine
[4] Institute of Medicinal Plants (ACECR),undefined
来源：
CNS Drugs | 2012年 / 26卷
关键词：
Ondansetron; Fluvoxamine; Granisetron; Quinpirole; Tropisetron;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Background: Several small studies have shown beneficial effects of ondansetron, a serotonin 5-HT3 receptor antagonist, in the treatment of obsessivecompulsive disorder (OCD). The efficacy of other 5-HT3 receptor antagonists in patients with OCD is still unclear. Granisetron does not alter cytochrome P450 activity and might have a lower risk of drug interactions, a longer duration of action and a better tolerability profile than other 5-HT3 receptor antagonists.
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页码：883 / 892
页数：9
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