Role of gut microbiota in doxorubicin-induced cardiotoxicity: from pathogenesis to related interventions

被引：6

作者：

Huang, Chao ^{[1
]}

Li, Xiaoxia ^{[2
]}

Li, Hanqing ^{[3
]}

Chen, Ruolan ^{[1
]}

Li, Zhaoqing ^{[1
]}

Li, Daisong ^{[1
]}

Xu, Xiaojian ^{[1
]}

Zhang, Guoliang ^{[1
]}

Qin, Luning ^{[1
]}

Li, Bing ^{[2
,4
]}

Chu, Xian-Ming ^{[1
,5
]}

机构：

[1] Qingdao Univ, Dept Cardiol, Affiliated Hosp, 59 Haier Rd, Qingdao 266100, Shandong, Peoples R China

[2] Qingdao Univ, Basic Med Coll, Dept Genet & Cell Biol, 308 Ningxia Rd, Qingdao 266000, Shandong, Peoples R China

[3] Qingdao Univ, Affiliated Hosp, Dept Gastroenterol, 16 Jiangsu Rd, Qingdao 266000, Peoples R China

[4] Qingdao Univ, Affiliated Haici Hosp, Dept Dermatol, Qingdao 266033, Peoples R China

[5] Qingdao Univ, Affiliated Cardiovasc Hosp, 5 Zhiquan Rd, Qingdao 266071, Peoples R China

来源：

JOURNAL OF TRANSLATIONAL MEDICINE | 2024年 / 22卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Cardiotoxicity; Doxorubicin; Gut microbiota; Metabolites; Interventions; Pathogenesis; TRIMETHYLAMINE-N-OXIDE; INTESTINAL BARRIER DYSFUNCTION; LACTIC-ACID BACTERIA; ANTHRACYCLINE CARDIOTOXICITY; INDUCED CARDIOMYOPATHY; OXIDATIVE STRESS; HEART-FAILURE; RISK; DYSBIOSIS; CONTRIBUTES;

D O I：

10.1186/s12967-024-05232-5

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Doxorubicin (DOX) is a broad-spectrum and highly efficient anticancer agent, but its clinical implication is limited by lethal cardiotoxicity. Growing evidences have shown that alterations in intestinal microbial composition and function, namely dysbiosis, are closely linked to the progression of DOX-induced cardiotoxicity (DIC) through regulating the gut-microbiota-heart (GMH) axis. The role of gut microbiota and its metabolites in DIC, however, is largely unelucidated. Our review will focus on the potential mechanism between gut microbiota dysbiosis and DIC, so as to provide novel insights into the pathophysiology of DIC. Furthermore, we summarize the underlying interventions of microbial-targeted therapeutics in DIC, encompassing dietary interventions, fecal microbiota transplantation (FMT), probiotics, antibiotics, and natural phytochemicals. Given the emergence of microbial investigation in DIC, finally we aim to point out a novel direction for future research and clinical intervention of DIC, which may be helpful for the DIC patients.

引用

页数：15

共 162 条

[1] Yogurt Containing the Probacteria Lactobacillus acidophilus Combined with Natural Antioxidants Mitigates Doxorubicin-Induced Cardiomyopathy in Rats [J].