Solid focal liver lesions: Dynamic and late enhancement patterns with the dual phase contrast agent gadobenate dimeglumine

被引：20

作者：

Grazioli L. ^{[1
]}

Bondioni M.P. ^{[1
]}

Faccioli N. ^{[2
]}

Gambarini S. ^{[1
]}

Tinti R. ^{[1
]}

Schneider G. ^{[3
]}

Kirchin M. ^{[4
]}

机构：

[1] Department of Radiology, University of Brescia, Brescia

[2] Department of Radiology, University of Verona, Verona

[3] Department of Radiology, University of Homburg, Saarland

[4] Bracco Medical Imaging, Milan

来源：

Journal of Gastrointestinal Cancer | 2010年 / 41卷 / 4期

关键词：

contrast media; liver; magnetic resonance imaging; meglumine;

D O I：

10.1007/s12029-010-9145-0

中图分类号：

学科分类号：

摘要：

Introduction: The purpose of this paper is to illustrate contrast enhancement patterns of solid focal liver lesions on dynamic and late phase imaging with gadobenate dimeglumine (Gd-BOPTA). Imaging Findings: Unenhanced T2- and T1-weighted, dynamic T1-weighted (arterial, portal-venous, and equilibrium) and late phase (1-3 h) Gd-BOPTA-enhanced MR imaging of different focal liver lesions (nodular regenerative hyperplasia, hepatic adenoma, liver adenomatosis, hepatocellular carcinoma, peripheral cholangiocarcinoma, hypervascular metastases, and hypovascular metastases) are shown. Dynamic imaging was performed using GRE T1-w sequences after the bolus injection of 0.1 mmol/kg Gd-BOPTA; late-phase imaging was obtained at 1-3 h after contrast injection. Conclusions: Dynamic imaging with Gd-BOPTA provides the same information as with conventional gadolinium-based extracellular contrast agents, while late-phase imaging gives additional information for lesion identification and characterization. © 2010 Springer Science+Business Media, LLC.

引用

页码：221 / 232

页数：11

共 46 条

[1]

Spinazzi A., Lorusso V., Pirovano G., Taroni P., Kirchin M., Davies A., MultiHance clinical pharmacology: Biodistribution and MR enhancement of the liver, Acad Radiol, 5, pp. 86-9, (1998)

[2]

Kirchin M.A., Pirovano G.P., Spinazzi A., Gadobenate dimeglumine (Gd-BOPTA): An overview, Investigative Radiology, 33, 11, pp. 798-809, (1998)

[3]

Spinazzi A., Lorusso V., Pirovano G., Kirchin M., Safety, tolerance, biodistribution and MR imaging enhancement of the liver with gadobenate dimeglumine, Acad Radiol, 6, pp. 282-91, (1999)

[4]

Cavagna F.M., Maggioni F., Castelli P.M., Dapra M., Imperatori L.G., Lorusso V., Jenkins B.G., Gadolinium chelates with weak binding to serum proteins: A new class of high-efficiency, general purpose contrast agents for magnetic resonance imaging, Investigative Radiology, 32, 12, pp. 780-796, (1997)

[5]

Giesel F.L., Von Tengg-Kobligk H., Wilkinson I.D., Siegler P., Von Der Lieth C.W., Frank M., Lodemann K.P., Essig M., Influence of human serum albumin on longitudinal and transverse relaxation rates (R1 and R2) of magnetic resonance contrast agents, Investigative Radiology, 41, 3, pp. 222-228, (2006)

[6]

De Haen C., Cabrini M., Akhnana L., Ratti D., Calabi L., Gozzini L., Gadobenate dimeglumine 0.5M solution for injection (MultiHance®): Pharmaceutical formulation and physicochemical properties of a new magnetic resonance imaging contrast medium, J Comput Assist Tomogr, 23, SUPPL. 1, pp. 161-8, (1999)

[7]

Pintaske J., Martirosian P., Graf H., Erb G., Lodemann K.-P., Claussen C.D., Schick F., Relaxivity of gadopentetate dimeglumine (Magnevist), gadobutrol (Gadovist), and gadobenate dimeglumine (MultiHance) in human blood plasma at 0.2, 1.5, and 3 Tesla, Investigative Radiology, 41, 3, pp. 213-221, (2006)

[8]

Schneider G., Maas R., Kool L.S., Rummeny E., Gehl H.-B., Lodemann K.-P., Kirchin M.A., Low-dose gadobenate dimeglumine versus standard dose gadopentetate dimeglumine for contrast-enhanced magnetic resonance imaging of the liver: An intra-individual crossover comparison, Investigative Radiology, 38, 2, pp. 85-94, (2003)

[9]

Kuwatsuru R., Kadoya M., Ohtomo K., Tanimoto A., Hirohashi S., Murakami T., Tanaka Y., Yoshikawa K., Katayama H., Comparison of gadobenate dimeglumine with gadopentetate dimeglumine for magnetic resonance imaging of liver tumors, Investigative Radiology, 36, 11, pp. 632-641, (2001)

[10]

Caudana R., Morana G., Pirovano G., Et al., Focal malignant hepatic lesions: MR imaging enhanced with gadolinium benzyloxypropionictetra-acetate (BOPTA) - Preliminary results of phase II clinical application, Radiology, 199, pp. 513-20, (1996)

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