Serum adipocyte fatty acid-binding protein in the critically ill

被引：0
作者：
Undurti N Das
机构：
[1] UND Life Sciences,
[2] Bio-Science Research Centre,undefined
[3] Gayatri Vidya Parishad College of Engineering,undefined
[4] Jawaharlal Nehru Technological University,undefined
来源：
Critical Care | / 17卷
关键词：
Arachidonic Acid; Unsaturated Fatty Acid; Experimental Autoimmune Encephalomyelitis; Systemic Insulin Sensitivity; Acid Arachidonic Acid;
D O I：
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摘要：
Sepsis due to unabated inflammation is common. Increased production of pro-inflammatory cytokines, free radicals, and eicosanoids has been detected in sepsis and other critical illnesses but could also be due to decreased synthesis and release of anti-inflammatory molecules. Increased serum adipose-fatty acid-binding protein (A-FABP) levels can cause insulin resistance and have been reported in the critically ill, serve as a marker of prognosis, and thus link metabolic homeostasis and inflammation. A-FABP can be linked to the expression of Toll-like receptors, macrophage activation, synthesis and release of pro-inflammatory cytokines interleukin-6 and tumor necrosis factor-alpha, activation of cyclooxygenase 2 (COX-2) expression, and eicosanoid synthesis, events that can cause insulin resistance and initiation and progression of inflammation and sepsis. Unsaturated fatty acids and their anti-inflammatory products, such as lipoxins, resolvins, and protectins, may suppress A-FABP expression, inhibit macrophage and COX-2 activation, and decrease production of pro-inflammatory cytokines and ultimately could lead to a decrease in insulin resistance and resolution of inflammation and recovery from sepsis. Serial measurement of these pro- and anti-inflammatory molecules and correlation of their levels to the progression to or recovery from (or both) sepsis and other inflammatory processes may form a new approach to predict prognosis in inflammatory conditions and eventually could lead to the development of new therapeutic strategies.
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