What's new in the diagnosis and management of painful bladder syndrome/interstitial cystitis?

被引：16
作者：
Seth A. [1 ]
Teichman J.M.H. [1 ]
机构：
[1] Division of Urology, St. Paul's Hospital, Burrard Building C307, Vancouver, BC V6Z 1Y6
来源：
Current Urology Reports | 2008年 / 9卷 / 5期
基金：
美国国家卫生研究院;
关键词：
Interstitial Cystitis; Sacral Nerve Stimulator; Sacral Neuromodulation; Chronic Pelvic Pain Syndrome; Bladder Pain;
D O I：
10.1007/s11934-008-0061-9
中图分类号：
学科分类号：
摘要：
Painful bladder syndrome/interstitial cystitis (PBS/IC) is a controversial subject. Despite its many controversies, recent data on diagnostics show that cystoscopy and hydrodtstension findings may not be sensitive or specific. Diagnosis is suggested primarily on the basis of history. Antiproliferative factor and Tamm-Horsfall protein are novel tests that may prove to be worthwhile pending future studies. Currently, there is no single diagnostic gold standard. Recent data on therapeutics show that, among oral therapies, amitriptyline and pentosan are efficacious. For best response, pentosan should be initiated early and used for a minimum of 6 months. Immune-modulating agents show promise but are limited by side effects. Intravesical alkalinized lidocaine with heparin may be effective for rapid symptom relief, pending results of prospective randomized trials. Intravesical botulinum toxin A, bacille Calmette- Guérin, and sacral neuromodulation may have a role in select patients. Copyright © 2008 by Current Medicine Group LLC.
引用
收藏
页码：349 / 357
页数：8
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