Drosophila TRP channels

被引：0
作者：
Craig Montell
机构：
[1] The Johns Hopkins University School of Medicine,Department of Biological Chemistry
来源：
Pflügers Archiv | 2005年 / 451卷
关键词：
TRP channel; Drosophila; Calcium; Sensory signaling;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The transient receptor potential (TRP) superfamily comprises a large group of related cation channels that display surprising diversity in the specific modes of activation and cation selectivities. However, a unifying theme is that many TRP channels play important roles in sensory physiology. The superfamily includes 28 mammalian members, which are subdivided into multiple subfamilies. Each of these subfamilies is represented by at least one of the 13 members in Drosophila, suggesting common evolutionary relationships. In recent years it has become clear that TRP channels in flies and mammals participate in similar sensory modalities. These include, but are not limited to, hearing, thermosensation, and certain specialized types of vision. With the recent flurry of new studies, 9 out of the 13 TRPs have been addressed in various contexts. As a result, the repertoire of biological roles attributed to Drosophila TRPs has increased considerably and is likely to lead to many additional surprises over the next few years.
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页码：19 / 28
页数：9
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  • [1] Acharya JK(1997)InsP Neuron 18 881-887
  • [2] Jalink K(2004) receptor essential for growth and differentiation but not for vision in Eur J Neurosci 20 2276-2282
  • [3] Hardy RW(2002)Two populations of cold-sensitive neurons in rat dorsal root ganglia and their modulation by nerve growth factor Neuron 34 83-93
  • [4] Hartenstein V(2004)Light-regulated subcellular translocation of Neuron 41 849-857
  • [5] Zuker CS(2000) TRPL channels induces long-term adaptation and modifies the light-induced current Nat Genet 26 118-123
  • [6] Babes A(2000)Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin Am J Hum Genet 67 1110-1120
  • [7] Zorzon D(2002)Identification of the gene causing mucolipidosis type IV Science 295 1070-1073
  • [8] Reid G(2004)Cloning of the gene encoding a novel integral membrane protein, mucolipidin- and identification of the two major founder mutations causing mucolipidosis type IV Nat Cell Biol 6 709-720
  • [9] Bähner M(2005)Phototransduction by retinal ganglion cells that set the circadian clock Dev Dyn 232 550-558
  • [10] Frechter S(2004)Rapid vesicular translocation and insertion of TRP channels J Biol Chem 279 7241-7246
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