Protective Effect of Carnosine on Cu,Zn-Superoxide Dismutase during Impaired Oxidative Metabolism in the Brain in Vivo

被引：0
|
作者：
S. L. Stvolinskii
T. N. Fedorova
M. O. Yuneva
A. A. Boldyrev
机构：
[1] Institute of Neurology,Russian Academy of Medical Sciences
来源：
Bulletin of Experimental Biology and Medicine | 2003年 / 135卷
关键词：
hypoxia; senescence accelerated mice (SAMP); Cu,Zn-SOD; brain; carnosine; antioxidants;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Natural hydrophilic antioxidant carnosine protects cerebral cytosolic Cu,Zn-superoxide dismutase (SOD) under conditions of oxidative stress in various in vivo models: short-term hypobaric hypoxia in rats and accumulation of age-related changes in senescence-accelerated mice (SAMP). Administration of carnosine preventing Cu,Zn-SOD inactivation reduced mortality in rats and prolonged average life span in SAMP-mice.
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页码：130 / 132
页数：2
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