Correlation between antimicrobial resistance and virulence in Klebsiella pneumoniae

被引：0
作者：
C. Hennequin
F. Robin
机构：
[1] CHU Clermont-Ferrand,Laboratoire de Bactériologie
[2] Université d’Auvergne,Clermont
[3] Université d’Auvergne,Université, UMR CNRS 6023, Laboratoire Microorganismes: Génome Environnement (LMGE)
[4] M2iSH,Clermont
[5] INSERM,Université
[6] U1071,Laboratoire associé Résistance des Entérobactéries BLSE/Céphalosporinases
[7] INRA USC2018,undefined
[8] Centre National de Référence Résistance aux Antibiotiques,undefined
来源：
European Journal of Clinical Microbiology & Infectious Diseases | 2016年 / 35卷
关键词：
Klebsiella Pneumoniae; Colistin; Cefoxitin; Aztreonam; Fitness Cost;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Klebsiella pneumoniae is responsible for a wide range of infections, including urinary tract infections, pneumonia, bacteremia, and liver abscesses. In addition to susceptible clinical isolates involved in nosocomial infections, multidrug-resistant (MDR) and hypervirulent (hvKP) strains have evolved separately in distinct clonal groups. The rapid geographic spread of these isolates is of particular concern. However, we still know little about the virulence of K. pneumoniae except for hvKP, whose secrets are beginning to be revealed. The treatment of K. pneumoniae infections is threatened by the emergence of antimicrobial resistance. The dissemination of resistance is associated with genetic mobile elements, such as plasmids that may also carry virulence determinants. A proficient pathogen should be virulent, resistant to antibiotics, and epidemic. However, the interplay between resistance and virulence is poorly understood. Here, we review current knowledge on the topic.
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页码：333 / 341
页数：8
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共 344 条
  • [41] Pan C-C(2001): identification and evolutionary scenario based on genomic and phenotypic characterization Antimicrob Agents Chemother 45 1151-88
  • [42] Tsai S-F(2013)Comparative study of genotype and virulence in CTX-M-producing and non-extended-spectrum-β-lactamase-producing PLoS One 8 e67847-384
  • [43] Peng H-L(2010) isolates Lancet Infect Dis 10 829-294
  • [44] Lin T-L(2004)Mapping the evolution of hypervirulent Antimicrob Agents Chemother 48 15-2705
  • [45] Lee C-Z(2013)A new fimbrial antigen harbored by CAZ-5/SHV-4-producing J Antimicrob Chemother 68 84-158
  • [46] Hsieh P-F(2012) strains involved in nosocomial infections Microb Drug Resist 18 380-990
  • [47] Tsai S-F(2015)Extended-spectrum beta-lactamase production is associated with an increase in cell invasion and expression of fimbrial adhesins in Future Microbiol 10 283-844
  • [48] Wang J-T(2014)Adhesive properties and antibiotic resistance of BMC Infect Dis 14 31-1493
  • [49] Chou H-C(2014), J Antimicrob Chemother 69 2699-4378
  • [50] Lee C-Z(2012), and Microbes Infect 14 155-462
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