Effects of dopaminergic and subthalamic stimulation on musical performance

被引：0

作者：

Floris T. van Vugt

Michael Schüpbach

Eckart Altenmüller

Eric Bardinet

Jérôme Yelnik

Thomas D. Hälbig

机构：

[1] Hannover University of Music,Institute of Music Physiology and Musicians’ Medicine

[2] Drama and Media,Lyon Neuroscience Research Center CNRS

[3] INSERM U1028,UMR 5292

[4] University Lyon-1,Département de Neurologie, Centre d’Investigation Clinique CIC

[5] Université Pierre et Marie Curie—Paris 6 et INSERM,9503, Assistance

[6] CHU Pitié-Salpêtrière,Publique Hôpitaux de Paris, Institut du Cerveau et de la Moelle épinière

[7] University Hospital,DBS

[8] Université Pierre et Marie Curie—Paris 6 UMR-S975,Unit, Movement Disorders Center, Department of Neurology

[9] INSERM U975,Centre de NeuroImagerie de Recherche, Institut du Cerveau et de la Moelle épinière

[10] CNRS UMR7225,Centre de Recherche de l’Institut du Cerveau et de la Moelle épinière

[11] CHU Pitié-Salpêtrière,Department of Neurology

[12] Universite Pierre et Marie Curie—Paris 6 UMR-S975,Department of Neurology

[13] INSERM U975,undefined

[14] CNRS UMR7225,undefined

[15] CHU Pitié-Salpêtrière,undefined

[16] Mount Sinai School of Medicine,undefined

[17] Charité—University Medical Center,undefined

来源：

Journal of Neural Transmission | 2013年 / 120卷

关键词：

Parkinson’s disease; Subthalamic nucleus; Deep brain stimulation; Dopamine; Motor control; Musical performance;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Although subthalamic-deep brain stimulation (STN-DBS) is an efficient treatment for Parkinson’s disease (PD), its effects on fine motor functions are not clear. We present the case of a professional violinist with PD treated with STN-DBS. DBS improved musical articulation, intonation and emotional expression and worsened timing relative to a timekeeper (metronome). The same effects were found for dopaminergic treatment. These results suggest that STN-DBS, mimicking the effects of dopaminergic stimulation, improves fine-tuned motor behaviour whilst impairing timing precision.

引用

页码：755 / 759

页数：4

共 48 条

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