Calcium channel blockers and pain therapy.

被引：0

作者：

Cox B. ^{[1
]}

机构：

[1] Glaxo Wellcome Research and Development, Department of Medicinal Chemistry 1, Medicines Research Centre, Gunnels Wood Road, Stevenage

来源：

Current Review of Pain | 2000年 / 4卷 / 6期

关键词：

Ziconotide; Cilnidipine; Calcium Channel Inhibitor; Fluspirilene; Benzylphenylether;

D O I：

10.1007/s11916-000-0073-8

中图分类号：

学科分类号：

摘要：

This review focuses on the advances in the development of N-type calcium channel blockers as analgesic agents over the last 2 years. Firstly, it highlights the clinical progress with SNX-111 (Ziconotide; Elan Pharmaceuticals, Smithfield, RI) and then secondly, it outlines the various approaches being taken by researchers to design orally active, selective, small molecule modulators without the perceived disadvantages associated with SNX-111.

引用

页码：488 / 498

页数：10

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