Midzone activation of aurora B in anaphase produces an intracellular phosphorylation gradient

被引：0
作者：
Brian G. Fuller
Michael A. Lampson
Emily A. Foley
Sara Rosasco-Nitcher
Kim V. Le
Page Tobelmann
David L. Brautigan
P. Todd Stukenberg
Tarun M. Kapoor
机构：
[1] University of Virginia School of Medicine,Departments of Biochemistry and Molecular Genetics
[2] Charlottesville,Department of Biology
[3] Virginia 22908,undefined
[4] USA,undefined
[5] University of Pennsylvania,undefined
[6] Philadelphia,undefined
[7] Pennsylvania 19104,undefined
[8] USA,undefined
[9] Laboratory of Chemistry and Cell Biology,undefined
[10] The Rockefeller University,undefined
[11] New York,undefined
[12] New York 10021,undefined
[13] USA,undefined
[14] Center for Cell Signaling,undefined
[15] University of Virginia School of Medicine,undefined
[16] Charlottesville,undefined
[17] Virginia 22908,undefined
[18] USA,undefined
来源：
Nature | 2008年 / 453卷
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学科分类号：
摘要：
Aurora B, a kinase important in mitosis, is now shown to generate a spatial gradient of phosphorylated substrates in anaphase with the highest concentration at the spindle midzone. Generation of this gradient involves a microtubule-dependent mechanism of aurora B activation. The gradient is proposed to provide important spatial information during mitosis.
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页码：1132 / 1136
页数：4
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