A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor–negative breast cancer

被引：0

作者：

Christopher A Haiman

Gary K Chen

Celine M Vachon

Federico Canzian

Alison Dunning

Robert C Millikan

Xianshu Wang

Foluso Ademuyiwa

Shahana Ahmed

Christine B Ambrosone

Laura Baglietto

Rosemary Balleine

Elisa V Bandera

Matthias W Beckmann

Christine D Berg

Leslie Bernstein

Carl Blomqvist

William J Blot

Hiltrud Brauch

Julie E Buring

Lisa A Carey

Jane E Carpenter

Jenny Chang-Claude

Stephen J Chanock

Daniel I Chasman

Christine L Clarke

Angela Cox

Simon S Cross

Sandra L Deming

Robert B Diasio

Athanasios M Dimopoulos

W Ryan Driver

Thomas Dünnebier

Lorraine Durcan

Diana Eccles

Christopher K Edlund

Arif B Ekici

Peter A Fasching

Heather S Feigelson

Dieter Flesch-Janys

Florentia Fostira

Asta Försti

George Fountzilas

Susan M Gerty

Graham G Giles

Andrew K Godwin

Paul Goodfellow

Nikki Graham

Dario Greco

Ute Hamann

机构：

[1] Keck School of Medicine,Department of Preventive Medicine

[2] University of Southern California/Norris Comprehensive Cancer Center,Department of Health Sciences Research

[3] Mayo Clinic,Department of Laboratory Medicine and Pathology

[4] Genomic Epidemiology Group,Department of Medicine

[5] DKFZ,Department of Cancer Prevention and Control

[6] Centre for Cancer Genetic Epidemiology,Department of Translational Oncology

[7] Strangeways Laboratory,Department of Gynecology and Obstetrics

[8] Lineberger Comprehensive Cancer Center,Division of Cancer Prevention

[9] University of North Carolina,Division of Cancer Etiology, Department of Population Science

[10] Mayo Clinic,Department of Oncology

[11] Roswell Park Cancer Institute,Division of Epidemiology, Department of Medicine

[12] Roswell Park Cancer Institute,Division of Preventive Medicine

[13] Cancer Epidemiology Centre,Department of Medicine

[14] The Cancer Council Victoria & Centre for Molecular,Division of Cancer Epidemiology

[15] Environmental,Division of Cancer Epidemiology and Genetics

[16] Genetic,Department of Oncology

[17] and Analytic Epidemiology,Department of Neuroscience

[18] The University of Melbourne,Department of Pharmacology

[19] Victoria,Department of Clinical Therapeutics

[20] Australia.,Department of Medicine, Division of Hematology and Oncology

[21] Westmead Hospital,Division of Molecular Genetic Epidemiology

[22] Western Sydney Local Health Network,Department of Medical Oncology

[23] The Cancer Institute of New Jersey,Department of Pathology and Laboratory Medicine

[24] University Hospital Erlangen,Department of Obstetrics and Gynecology

[25] Friedrich-Alexander University Erlangen-Nuremberg,Department of Medicine

[26] National Cancer Institute,Department of Epidemiology

[27] US National Institutes of Health,Sylvester Comprehensive Cancer Center and Department of Epidemiology and Public Health

[28] Beckman Research Institute,Human Genetics Division

[29] Helsinki University Central Hospital,Department of Oncology

[30] Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center,Division of Cancer Epidemiology

[31] Vanderbilt University School of Medicine,Department of Internal Medicine

[32] International Epidemiology Institute,Department of Pathology

[33] Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology,Department of Surgical Oncology

[34] University of Tübingen,Department of Pathology

[35] Brigham and Women's Hospital,Department of Pathology

[36] Lineberger Comprehensive Cancer Center,Department of Clinical Genetics

[37] University of North Carolina,Department of Medical Oncology

[38] Australian Breast Cancer Tissue Bank,Department of Internal Medicine

[39] University of Sydney at the Westmead Millennium Institute,Departments of Genetics and Pathology

[40] German Cancer Research Center,Department of Epidemiology and Population Health

[41] National Cancer Institute,Department of Pathology

[42] US National Institutes of Health,Department of Clinical Genetics and Biocenter Oulu

[43] Institute for Cancer Studies,Department of Biostatistics

[44] Faculty of Medicine,Division of Experimental Therapy and Molecular Pathology and Division of Epidemiology

[45] Dentistry & Health,Department of Pathology

[46] University of Sheffield,Department of Pathology

[47] Academic Unit of Pathology,Department of Biostatistics

[48] Faculty of Medicine,undefined

[49] Dentistry & Health,undefined

[50] University of Sheffield,undefined

来源：

Nature Genetics | 2011年 / 43卷

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摘要：

Christopher Haiman and colleagues report a genome-wide association study for estrogen receptor (ER)-negative breast cancer in women of African and European ancestry. They identify a variant at the TERT-CLPTM1L locus on 5p15 as associated with ER-negative and triple-negative breast cancer. This locus also harbors multiple variants associated with a range of other cancers.

引用

页码：1210 / 1214

页数：4

共 15 条

[11] Baird DM(2010)Variation at the TERT locus and predisposition for cancer Expert Rev. Mol. Med. 12 e16-1406
[12] Johnatty SE(2010)Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility “hot-spot” PLoS Genet. 6 e1001016-904
[13] McKay JD(2008)Lung cancer susceptibility locus at 5p15.33 Nat. Genet. 40 1404-884
[14] Shete S(2009)Genome-wide association study identifies five susceptibility loci for glioma Nat. Genet. 41 899-undefined
[15] Bolton KL(2010)Common variants at 19p13 are associated with susceptibility to ovarian cancer Nat. Genet. 42 880-undefined

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