A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor–negative breast cancer

被引:0
作者
Christopher A Haiman
Gary K Chen
Celine M Vachon
Federico Canzian
Alison Dunning
Robert C Millikan
Xianshu Wang
Foluso Ademuyiwa
Shahana Ahmed
Christine B Ambrosone
Laura Baglietto
Rosemary Balleine
Elisa V Bandera
Matthias W Beckmann
Christine D Berg
Leslie Bernstein
Carl Blomqvist
William J Blot
Hiltrud Brauch
Julie E Buring
Lisa A Carey
Jane E Carpenter
Jenny Chang-Claude
Stephen J Chanock
Daniel I Chasman
Christine L Clarke
Angela Cox
Simon S Cross
Sandra L Deming
Robert B Diasio
Athanasios M Dimopoulos
W Ryan Driver
Thomas Dünnebier
Lorraine Durcan
Diana Eccles
Christopher K Edlund
Arif B Ekici
Peter A Fasching
Heather S Feigelson
Dieter Flesch-Janys
Florentia Fostira
Asta Försti
George Fountzilas
Susan M Gerty
Graham G Giles
Andrew K Godwin
Paul Goodfellow
Nikki Graham
Dario Greco
Ute Hamann
机构
[1] Keck School of Medicine,Department of Preventive Medicine
[2] University of Southern California/Norris Comprehensive Cancer Center,Department of Health Sciences Research
[3] Mayo Clinic,Department of Laboratory Medicine and Pathology
[4] Genomic Epidemiology Group,Department of Medicine
[5] DKFZ,Department of Cancer Prevention and Control
[6] Centre for Cancer Genetic Epidemiology,Department of Translational Oncology
[7] Strangeways Laboratory,Department of Gynecology and Obstetrics
[8] Lineberger Comprehensive Cancer Center,Division of Cancer Prevention
[9] University of North Carolina,Division of Cancer Etiology, Department of Population Science
[10] Mayo Clinic,Department of Oncology
[11] Roswell Park Cancer Institute,Division of Epidemiology, Department of Medicine
[12] Roswell Park Cancer Institute,Division of Preventive Medicine
[13] Cancer Epidemiology Centre,Department of Medicine
[14] The Cancer Council Victoria & Centre for Molecular,Division of Cancer Epidemiology
[15] Environmental,Division of Cancer Epidemiology and Genetics
[16] Genetic,Department of Oncology
[17] and Analytic Epidemiology,Department of Neuroscience
[18] The University of Melbourne,Department of Pharmacology
[19] Victoria,Department of Clinical Therapeutics
[20] Australia.,Department of Medicine, Division of Hematology and Oncology
[21] Westmead Hospital,Division of Molecular Genetic Epidemiology
[22] Western Sydney Local Health Network,Department of Medical Oncology
[23] The Cancer Institute of New Jersey,Department of Pathology and Laboratory Medicine
[24] University Hospital Erlangen,Department of Obstetrics and Gynecology
[25] Friedrich-Alexander University Erlangen-Nuremberg,Department of Medicine
[26] National Cancer Institute,Department of Epidemiology
[27] US National Institutes of Health,Sylvester Comprehensive Cancer Center and Department of Epidemiology and Public Health
[28] Beckman Research Institute,Human Genetics Division
[29] Helsinki University Central Hospital,Department of Oncology
[30] Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center,Division of Cancer Epidemiology
[31] Vanderbilt University School of Medicine,Department of Internal Medicine
[32] International Epidemiology Institute,Department of Pathology
[33] Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology,Department of Surgical Oncology
[34] University of Tübingen,Department of Pathology
[35] Brigham and Women's Hospital,Department of Pathology
[36] Lineberger Comprehensive Cancer Center,Department of Clinical Genetics
[37] University of North Carolina,Department of Medical Oncology
[38] Australian Breast Cancer Tissue Bank,Department of Internal Medicine
[39] University of Sydney at the Westmead Millennium Institute,Departments of Genetics and Pathology
[40] German Cancer Research Center,Department of Epidemiology and Population Health
[41] National Cancer Institute,Department of Pathology
[42] US National Institutes of Health,Department of Clinical Genetics and Biocenter Oulu
[43] Institute for Cancer Studies,Department of Biostatistics
[44] Faculty of Medicine,Division of Experimental Therapy and Molecular Pathology and Division of Epidemiology
[45] Dentistry & Health,Department of Pathology
[46] University of Sheffield,Department of Pathology
[47] Academic Unit of Pathology,Department of Biostatistics
[48] Faculty of Medicine,undefined
[49] Dentistry & Health,undefined
[50] University of Sheffield,undefined
来源
Nature Genetics | 2011年 / 43卷
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摘要
Christopher Haiman and colleagues report a genome-wide association study for estrogen receptor (ER)-negative breast cancer in women of African and European ancestry. They identify a variant at the TERT-CLPTM1L locus on 5p15 as associated with ER-negative and triple-negative breast cancer. This locus also harbors multiple variants associated with a range of other cancers.
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页码:1210 / 1214
页数:4
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