A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor–negative breast cancer

被引：0

作者：

Christopher A Haiman

Gary K Chen

Celine M Vachon

Federico Canzian

Alison Dunning

Robert C Millikan

Xianshu Wang

Foluso Ademuyiwa

Shahana Ahmed

Christine B Ambrosone

Laura Baglietto

Rosemary Balleine

Elisa V Bandera

Matthias W Beckmann

Christine D Berg

Leslie Bernstein

Carl Blomqvist

William J Blot

Hiltrud Brauch

Julie E Buring

Lisa A Carey

Jane E Carpenter

Jenny Chang-Claude

Stephen J Chanock

Daniel I Chasman

Christine L Clarke

Angela Cox

Simon S Cross

Sandra L Deming

Robert B Diasio

Athanasios M Dimopoulos

W Ryan Driver

Thomas Dünnebier

Lorraine Durcan

Diana Eccles

Christopher K Edlund

Arif B Ekici

Peter A Fasching

Heather S Feigelson

Dieter Flesch-Janys

Florentia Fostira

Asta Försti

George Fountzilas

Susan M Gerty

Graham G Giles

Andrew K Godwin

Paul Goodfellow

Nikki Graham

Dario Greco

Ute Hamann

机构：

[1] Keck School of Medicine,Department of Preventive Medicine

[2] University of Southern California/Norris Comprehensive Cancer Center,Department of Health Sciences Research

[3] Mayo Clinic,Department of Laboratory Medicine and Pathology

[4] Genomic Epidemiology Group,Department of Medicine

[5] DKFZ,Department of Cancer Prevention and Control

[6] Centre for Cancer Genetic Epidemiology,Department of Translational Oncology

[7] Strangeways Laboratory,Department of Gynecology and Obstetrics

[8] Lineberger Comprehensive Cancer Center,Division of Cancer Prevention

[9] University of North Carolina,Division of Cancer Etiology, Department of Population Science

[10] Mayo Clinic,Department of Oncology

[11] Roswell Park Cancer Institute,Division of Epidemiology, Department of Medicine

[12] Roswell Park Cancer Institute,Division of Preventive Medicine

[13] Cancer Epidemiology Centre,Department of Medicine

[14] The Cancer Council Victoria & Centre for Molecular,Division of Cancer Epidemiology

[15] Environmental,Division of Cancer Epidemiology and Genetics

[16] Genetic,Department of Oncology

[17] and Analytic Epidemiology,Department of Neuroscience

[18] The University of Melbourne,Department of Pharmacology

[19] Victoria,Department of Clinical Therapeutics

[20] Australia.,Department of Medicine, Division of Hematology and Oncology

[21] Westmead Hospital,Division of Molecular Genetic Epidemiology

[22] Western Sydney Local Health Network,Department of Medical Oncology

[23] The Cancer Institute of New Jersey,Department of Pathology and Laboratory Medicine

[24] University Hospital Erlangen,Department of Obstetrics and Gynecology

[25] Friedrich-Alexander University Erlangen-Nuremberg,Department of Medicine

[26] National Cancer Institute,Department of Epidemiology

[27] US National Institutes of Health,Sylvester Comprehensive Cancer Center and Department of Epidemiology and Public Health

[28] Beckman Research Institute,Human Genetics Division

[29] Helsinki University Central Hospital,Department of Oncology

[30] Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center,Division of Cancer Epidemiology

[31] Vanderbilt University School of Medicine,Department of Internal Medicine

[32] International Epidemiology Institute,Department of Pathology

[33] Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology,Department of Surgical Oncology

[34] University of Tübingen,Department of Pathology

[35] Brigham and Women's Hospital,Department of Pathology

[36] Lineberger Comprehensive Cancer Center,Department of Clinical Genetics

[37] University of North Carolina,Department of Medical Oncology

[38] Australian Breast Cancer Tissue Bank,Department of Internal Medicine

[39] University of Sydney at the Westmead Millennium Institute,Departments of Genetics and Pathology

[40] German Cancer Research Center,Department of Epidemiology and Population Health

[41] National Cancer Institute,Department of Pathology

[42] US National Institutes of Health,Department of Clinical Genetics and Biocenter Oulu

[43] Institute for Cancer Studies,Department of Biostatistics

[44] Faculty of Medicine,Division of Experimental Therapy and Molecular Pathology and Division of Epidemiology

[45] Dentistry & Health,Department of Pathology

[46] University of Sheffield,Department of Pathology

[47] Academic Unit of Pathology,Department of Biostatistics

[48] Faculty of Medicine,undefined

[49] Dentistry & Health,undefined

[50] University of Sheffield,undefined

来源：

Nature Genetics | 2011年 / 43卷

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摘要：

Christopher Haiman and colleagues report a genome-wide association study for estrogen receptor (ER)-negative breast cancer in women of African and European ancestry. They identify a variant at the TERT-CLPTM1L locus on 5p15 as associated with ER-negative and triple-negative breast cancer. This locus also harbors multiple variants associated with a range of other cancers.

引用

页码：1210 / 1214

页数：4

共 15 条

[1] Carey LA(2006)Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study J. Am. Med. Assoc. 295 2492-2502
[2] Huo D(2009)Population differences in breast cancer: survey in indigenous African women reveals over-representation of triple-negative breast cancer J. Clin. Oncol. 27 4515-4521
[3] Sørlie T(2001)Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications Proc. Natl. Acad. Sci. USA 98 10869-10874
[4] Antoniou AC(2010)A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population Nat. Genet. 42 885-892
[5] Easton DF(2007)Genome-wide association study identifies novel breast cancer susceptibility loci Nature 447 1087-1093
[6] Haiman CA(2007)A common genetic risk factor for colorectal and prostate cancer Nat. Genet. 39 954-956
[7] Kiemeney LA(2008)Sequence variant on 8q24 confers susceptibility to urinary bladder cancer Nat. Genet. 40 1307-1312
[8] Purdue MP(2011)Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3 Nat. Genet. 43 60-65
[9] Thomas G(2008)Multiple loci identified in a genome-wide association study of prostate cancer Nat. Genet. 40 310-315
[10] Turnbull C(2010)Genome-wide association study identifies five new breast cancer susceptibility loci Nat. Genet. 42 504-507

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