Treatment of imported severe malaria with artesunate instead of quinine - more evidence needed?

被引：0
作者：
Jakob P Cramer
Rogelio López-Vélez
Gerd D Burchard
Martin P Grobusch
Peter J de Vries
机构：
[1] University Medical Center Hamburg-Eppendorf,Bernhard Nocht Clinic for Tropical Medicine, I. Department of Tropical Medicine
[2] University of Alcalá,Department of Infectious Diseases, Tropical Medicine and Clinical Parasitology, Ramón y Cajal Hospital
[3] University of Amsterdam,Division of Infectious Diseases, Tropical Medicine and AIDS, Department of Medicine, Amsterdam Medical Center
来源：
Malaria Journal | / 10卷
关键词：
Malaria; Quinine; Severe Malaria; Artesunate; Endemic Country;
D O I：
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中图分类号：
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摘要：
Rapid and fast acting anti-malarials are essential to treat severe malaria. Quinine has been the only option for parenteral therapy until recently. While current evidence shows that intravenous artesunate is more effective than quinine in treating severe malaria in endemic countries, some questions remain regarding safety profiles and drug resistance. For imported severe malaria, additional unanswered questions are related to generalizability of the findings from endemic countries and to legal aspects, as there is no Good Manufacturing Practice-conform drug available yet. Here, the implications of existing evidence for the treatment of imported severe malaria are discussed.
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