Detection limit of 89Zr-labeled T cells for cellular tracking: an in vitro imaging approach using clinical PET/CT and PET/MRI

被引:0
作者
Laura M. Lechermann
Roido Manavaki
Bala Attili
Doreen Lau
Lorna B. Jarvis
Tim D. Fryer
Nick Bird
Luigi Aloj
Neel Patel
Bristi Basu
Matthew Cleveland
Franklin I. Aigbirhio
Joanne L. Jones
Ferdia A. Gallagher
机构
[1] University of Cambridge,Department of Radiology
[2] University of Cambridge,Cancer Research UK Cambridge Institute
[3] University of Cambridge,Wolfson Brain Imaging Centre
[4] University of Cambridge,Department of Clinical Neurosciences
[5] Addenbrooke’s Hospital,Department of Nuclear Medicine
[6] GSK Medicines Research Centre,Department of Oncology
[7] University of Cambridge,undefined
来源
EJNMMI Research | / 10卷
关键词
PET; Cell labeling; Cell tracking; Zirconium-89; Detection limit;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 64 条
[1]  
Boyiadzis MM(2018)Chimeric antigen receptor (CAR) T therapies for the treatment of hematologic malignancies: clinical perspective and significance J Immunother Cancer. 6 137-6115
[2]  
Dhodapkar MV(2006)A phase I study on adoptive immunotherapy using gene-modified T cells for ovarian cancer Clin Cancer Res. 12 6106-1533
[3]  
Brentjens RJ(2013)Targeting of 111In-labeled dendritic cell human vaccines improved by reducing number of cells Clin Cancer Res. 19 1525-1122
[4]  
Kershaw MH(2016)Concurrent SPECT/PET-CT imaging as a method for tracking adoptively transferred T-cells in vivo J Immunother Cancer. 4 27-58
[5]  
Westwood JA(2017)Safety, tumor trafficking and immunogenicity of chimeric antigen receptor (CAR)-T cells specific for TAG-72 in colorectal cancer J Immunother Cancer. 5 22-2768
[6]  
Parker LL(2015)FHBG PET/CT imaging of CD34-TK75 transduced donor T cells in relapsed allogeneic stem cell transplant patients: Safety and feasibility Mol Ther. 23 1110-500
[7]  
Aarntzen EHJG(2010)In vivo imaging and monitoring of transplanted stem cells: clinical applications Curr. Cardiol. Rep. 12 51-229
[8]  
Srinivas M(2017)Bone marrow cell trafficking analyzed by 89Zr-oxine positron emission tomography in a murine transplantation model Clin Cancer Res. 23 2759-739
[9]  
Bonetto F(2015)Zr-oxine complex PET cell imaging in monitoring cell-based therapies Radiology. 275 490-229
[10]  
Stanton SE(2019)In vivo PET tracking of 89Zr-labeled Vγ9Vδ2 T cells to mouse xenograft breast tumors activated with liposomal alendronate Mol Ther. 27 219-123