Common variants in DVWA on chromosome 3p24.3 are associated with susceptibility to knee osteoarthritis

被引:0
作者
Yoshinari Miyamoto
Dongquan Shi
Masahiro Nakajima
Kouichi Ozaki
Akihiro Sudo
Akihiro Kotani
Atsumasa Uchida
Toshihiro Tanaka
Naoshi Fukui
Tatsuhiko Tsunoda
Atsushi Takahashi
Yusuke Nakamura
Qing Jiang
Shiro Ikegawa
机构
[1] Laboratory for Bone and Joint Diseases,Department of Orthopaedic Surgery
[2] Center for Genomic Medicine,Department of Orthopaedic Surgery
[3] RIKEN,Department of Pathomechanisms
[4] 4-6-1 Shirokanedai,undefined
[5] The Center of Diagnosis and Treatment for Joint Disease,undefined
[6] Drum Tower Hospital Affiliated to Medical School of Nanjing University,undefined
[7] Laboratory for Cardiovascular Diseases,undefined
[8] Center for Genomic Medicine,undefined
[9] RIKEN,undefined
[10] 1-7-22 Suehiro-cho,undefined
[11] Mie University Faculty of Medicine,undefined
[12] 2-174 Edobashi,undefined
[13] Tsu,undefined
[14] Mie,undefined
[15] Kyorin University,undefined
[16] School of Medicine,undefined
[17] 6-20-2 Shinkawa,undefined
[18] Clinical Research Center for Rheumatology and Allergy,undefined
[19] National Hospital Organization Sagamihara National Hospital,undefined
[20] 18-1 Sakuradai,undefined
[21] The Laboratory for Medical Informatics,undefined
[22] Center for Genomic Medicine,undefined
[23] RIKEN,undefined
[24] 1-7-22 Suehiro-cho,undefined
[25] Tsurumi-ku,undefined
[26] Laboratory for Statistical Analysis,undefined
[27] Center for Genomic Medicine,undefined
[28] RIKEN,undefined
[29] 4-6-1 Shirokanedai,undefined
[30] Minato-ku,undefined
[31] Laboratory for Genotyping,undefined
[32] Center for Genomic Medicine,undefined
[33] RIKEN,undefined
[34] 4-6-1 Shirokanedai,undefined
[35] Minato-ku,undefined
来源
Nature Genetics | 2008年 / 40卷
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中图分类号
学科分类号
摘要
Shiro Ikegawa and colleagues identify a variant in a newly identified gene, DVWA, that is associated with susceptibility to knee osteoarthritis. DVWA contains von Willebrand factor domains and is expressed specifically in cartilage.
引用
收藏
页码:994 / 998
页数:4
相关论文
共 57 条
[11]  
Laporte A(2006)Replication of the association of the aspartic acid repeat polymorphism in the asporin gene with knee-osteoarthritis susceptibility in Han Chinese J. Hum. Genet. 51 1068-1072
[12]  
Croxford R(2007)Sex and ethnic differences in the association of ASPN, CALM1, COL2A1, COMP, and FRZB with genetic susceptibility to osteoarthritis of the knee Arthritis Rheum. 56 137-146
[13]  
Coyte PC(2002)Functional SNPs in the lymphotoxin-alpha gene that are associated with susceptibility to myocardial infarction Nat. Genet. 32 650-654
[14]  
Spector TD(2005)A functional single nucleotide polymorphism in the core promoter region of CALM1 is associated with hip osteoarthritis in Japanese Hum. Mol. Genet. 14 1009-1017
[15]  
Cicuttini F(2007)A nonsynonymous SNP in PRKCH (protein kinase C eta) increases the risk of cerebral infarction Nat. Genet. 39 212-217
[16]  
Baker J(2002)Gene-based SNP discovery as part of the Japanese Millennium Genome Project: identification of 190,562 genetic variations in the human genome. Single-nucleotide polymorphism J. Hum. Genet. 47 605-610
[17]  
Loughlin J(1999)Use of unlinked genetic markers to detect population stratification in association studies Am. J. Hum. Genet. 65 220-228
[18]  
Hart D(2004)Assessing the impact of population stratification on genetic association studies Nat. Genet. 36 388-393
[19]  
Loughlin J(2007)A new JAVA interface implementation of THESIAS: testing haplotype effects in association studies Bioinformatics 23 1038-1039
[20]  
Kizawa H(2003)Genomewide scan for hand osteoarthritis: a novel mutation in matrilin-3 Am. J. Hum. Genet. 72 1448-1459