On the role of tyrosine phosphatases as negative regulators of STAT signaling in breast cancers: new findings and future perspectives

被引：0
作者：
Michel L Tremblay
机构：
[1] McGill University,Room 613, Cancer Building
来源：
Breast Cancer Research | / 15卷
关键词：
Breast Cancer; Epidermal Growth Factor Receptor; Human Breast Primary Tumor; Family Protein Tyrosine Kinase; Breast Primary Tumor Cell;
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摘要：
The increasing importance of signal transducer and activator of transcription 3 (STAT3) expression in human cancers has led several laboratories to examine in detail the expression of one of its major negative regulators in oncogenesis - the T-cell protein tyrosine phosphatase, nonreceptor type 2 (PTPN2). A recent paper by Shields and colleagues points to the associate depletion of PTPN2 in STAT3-positive breast cancers. We examine these findings and reflect on the mechanism of action of PTPN2 and the consequences of its modulation for STAT3 downstream signaling.
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