Drug-associated kidney injury in children: a disproportionality analysis of the FDA Adverse Event Reporting System

被引：0
作者：
Miao Zhang
Hailong Li
Liang Huang
Yan Liu
Xue-Feng Jiao
Linan Zeng
Zhi-Jun Jia
Guo Cheng
Lingli Zhang
Wei Zhang
机构：
[1] West China Second University Hospital,Department of Pharmacy
[2] Sichuan University,Evidence
[3] West China Second University Hospital,Based Pharmacy Center
[4] Sichuan University,Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education
[5] NMPA Key Laboratory for Technical Research On Drug Products In Vitro and In Vivo Correlation,West China School of Pharmacy
[6] Sichuan University,Department of Pediatrics
[7] Sichuan University,Laboratory of Molecular Translational Medicine, Center for Translational Medicine
[8] West China Second University Hospital,West China Biomedical Big Data Center
[9] Sichuan University,Medical Big Data Center
[10] Sichuan University,Chinese Evidence
[11] West China Hospital,Based Medicine Center
[12] Sichuan University,undefined
[13] Sichuan University,undefined
[14] West China Hospital,undefined
[15] Sichuan University,undefined
来源：
European Journal of Pediatrics | 2023年 / 182卷
关键词：
Drug-associated kidney injury; Children; Disproportionality; FAERS;
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学科分类号：
摘要：
Drug-associated kidney injury is related to longer hospitalization and increased risk of chronic kidney disease and mortality. However, there is currently a lack of large population studies on drug-associated kidney injury in children. This study aimed to study perform data mining to generate hypotheses on drugs, which may deserve to be assessed as per their potential risk of increasing kidney injury in children. We extracted and analyzed reports on drugs associated with kidney injury in children in the FDA Adverse Event Reporting System (FAERS). We conducted a disproportionality analysis using proportional reporting ratio (PRR) to evaluate the association between drugs and kidney injury in children. Meanwhile, comparisons were performed with drug labels to identify drugs that, despite not having kidney injury currently mentioned in their labels, may potentially be associated with risks of kidney injury in children. A total of 6347 children had drug-associated kidney injury in the FAERS database. The top five drugs with the highest PRR were gentamicin (PRR = 12.28, N = 157 cases, Chi-Squared = 1602.77), piperacillin-tazobactam (PRR = 9.77, N = 129 cases, Chi-Squared = 1003.24), amlodipine (PRR = 8.98, N = 271 cases, Chi-Squared = 1861.46), vancomycin (PRR = 8.91, N = 295 cases, Chi-Squared = 1998.64), and ceftriaxone (PRR = 8.00, N = 251 cases, Chi-Squared = 1494.02). According to drug labels, 9 drugs (9/30) were classified as potential nephrotoxins.
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页码：4655 / 4661
页数：6
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