Free-radical scavenging activity of radioprotectors: comparison between clinically used radioprotectors and natural antioxidants

被引：0
作者：
Yoshimi Sueishi
Takumi Fujii
Risako Nii
机构：
[1] Okayama University,Department of Chemistry, Faculty of Science
来源：
Journal of Radioanalytical and Nuclear Chemistry | 2020年 / 325卷
关键词：
Natural antioxidant; Antioxidant ability; Radioprotective effect; MULTIS; ESR spin trapping;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Clinically used radioprotectors, amifostine and cysteamine, have been shown to possess free-radical scavenging activities. Natural antioxidants also possess free-radical scavenging activities, some of which have been shown to have radioprotective capability. We carried out a quantitative determination of the scavenging abilities in amifostine and cysteamine and compared the potencies with natural antioxidants by using multiple free-radical scavenging method. Overall, amifostine and cysteamine showed scavenging activity as potent as natural antioxidants. We found a correlation between scavenging activity and radioprotective efficiency that was previously determined in rat thymocytes. These correlations are indicative that natural antioxidants can be effective radioprotectors.
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页码：695 / 700
页数：5
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