Skeletal myogenesis by human embryonic stem cells

被引:0
作者
Jun Ke Zheng
Yi Wang
Aditi Karandikar
Qian Wang
Hui Gai
Ai Lian Liu
Chao Peng
Hui Zhen Sheng
机构
[1] Center for Developmental Biology,
[2] Xinhua Hospital,undefined
[3] School of Medicine,undefined
[4] Shanghai Jiao Tong University,undefined
[5] Laboratory of Stem Cell Biology,undefined
[6] Institute of Biochemistry and Cell Biology,undefined
[7] Shanghai Institutes of Biological Sciences,undefined
[8] Chinese Academy of Sciences,undefined
来源
Cell Research | 2006年 / 16卷
关键词
Skeletal myogenesis; embryonic stem cell; differentiation;
D O I
暂无
中图分类号
学科分类号
摘要
We have examined the myogenic potential of human embryonic stem (hES) cells in a xeno-transplantation animal model. Here we show that precursors differentiated from hES cells can undergo myogenesis in an adult environment and give rise to a range of cell types in the myogenic lineage. This study provides direct evidences that hES cells can regenerate both muscle and satellite cells in vivo and are another promising cell type for treating muscle degenerative disorders in addition to other myogenic cell types.
引用
收藏
页码:713 / 722
页数:9
相关论文
共 82 条
[1]  
Mauro A(1961)Satellite cell of skeletal muscle fibers J Biophys Biochem Cytol 9 493-495
[2]  
Jejurikar SS(2003)Satellite cell depletion in degenerative skeletal muscle Apoptosis 8 573-578
[3]  
Kuzon WM(1995)Myoblast transfer in the treatment of Duchenne's muscular dystrophy N Engl J Med 333 832-838
[4]  
Mendell JR(1990)Accelerated age-related decline in replicative life-span of Duchenne muscular dystrophy myoblasts: implications for cell and gene therapy Somat Cell Mol Genet 16 557-565
[5]  
Kissel JT(1999)Dynamics of myoblast transplantation reveal a discrete minority of precursors with stem cell-like properties as the myogenic source J Cell Biol 144 1113-1122
[6]  
Amato AA(1999)Skeletal myogenic progenitors originating from embryonic dorsal aorta coexpress endothelial and myogenic markers and contribute to postnatal muscle growth and regeneration J Cell Biol 147 869-878
[7]  
Webster C(1998)Muscle regeneration by bone marrow-derived myogenic progenitors Science 279 1528-1530
[8]  
Blau HM(2003)Single hematopoietic stem cells generate skeletal muscle through myeloid intermediates Nat Med 9 1520-1527
[9]  
Beauchamp JR(1999)Dystrophin expression in the mdx mouse restored by stem cell transplantation Nature 401 390-394
[10]  
Morgan JE(1999)Hematopoietic potential of stem cells isolated from murine skeletal muscle Proc Natl Acad Sci USA 96 14482-14486