Comparative Pharmacokinetics and Pharmacodynamics of Short-Acting HypnosedativesZaleplon, Zolpidem and Zopiclone

被引：0
|
作者：
David R. Drover
机构：
[1] Stanford University School of Medicine,Department of Anesthesia
来源：
Clinical Pharmacokinetics | 2004年 / 43卷
关键词：
GABAA Receptor; Zolpidem; Gaba Receptor; Zopiclone; Zaleplon;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Benzodiazepines have historically been the mainstay of treatment for sleeping disorders, yet they have many shortcomings. A new group of sedative hypnotic agents has been developed for this purpose. Similar to the benzodiazepines, zaleplon, zolpidem and zopiclone have activity at the GABA receptor complex, yet they appear to have more selectivity for certain subunits of the GABA receptor. This produces a clinical profile that is more efficacious with fewer side effects. Zaleplon, zolpidem and zopiclone are structurally distinct. Due to variation in binding to the GABA receptor subunits, these three compounds show subtle differences in their effect on sleep stages, and as antiepileptics, anxiolytics and amnestics.
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页码：227 / 238
页数：11
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