Host Innate Immune Response to Mycobacterium tuberculosis

被引：0
作者：
Kamlesh Bhatt
Padmini Salgame
机构：
[1] UMDNJ-New Jersey Medical School,Department of Medicine, Centre for Emerging Pathogens
来源：
Journal of Clinical Immunology | 2007年 / 27卷
关键词：
innate immunity; TLR2; dendritic cells; macrophages;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
This review focuses on recent progress in our understanding of Mycobacterium tuberculosis survival in macrophages, the interaction of M. tuberculosis with Toll-like receptors (TLRs) and the establishment of the link between innate and adaptive immunity, and TLRs and interferon-γ-mediated antimicrobial pathways in macrophages. We also propose a paradigm that TLR2 signaling regulates the magnitude of the host Th1 response leading to either M. tuberculosis persistence and latent infection or replication and disease.
引用
收藏
页码：347 / 362
页数：15
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