Role of the retinoblastoma protein family, pRB, p107 and p130 in the negative control of cell growth

被引:0
作者
Xavier Graña
Judit Garriga
Xavier Mayol
机构
[1] Temple University School of Medicine,Fels Institute for Cancer Research and Molecular Biology and Department of Biochemistry
[2] Unitat de Biologia Cel.lular i Molecular,undefined
[3] Institut Municipal d' Investigació Medica (IMIM),undefined
来源
Oncogene | 1998年 / 17卷
关键词
CDK; CKI; transcriptional regulation; cyclins; cell cycle;
D O I
暂无
中图分类号
学科分类号
摘要
The retinoblastoma family of proteins, also known as pocket proteins, includes the product of the retinoblastoma susceptibility gene and the functionally and structurally related proteins p107 and p130. Pocket proteins control growth processes in many cell types, and this has been linked to the ability of pocket proteins to interact with a multitude of cellular proteins that regulate gene expression at various levels. By regulating gene expression, pocket proteins control cell cycle progression, cell cycle entry and exit, cell differentiation and apoptosis. This review will focus on the mechanisms of regulation of pocket proteins and how modulation of pocket protein levels and phosphorylation status regulate association with their cellular targets. The coordinated regulation of pocket proteins provides the cells with a competence mechanism for passage through certain cell growth and differentiation transitions.
引用
收藏
页码:3365 / 3383
页数:18
相关论文
共 45 条
[31]   CELL CYCLE-DEPENDENT ALTERATIONS OF A HIGHLY PHOSPHORYLATED NUCLEOLAR PROTEIN P130 ARE ASSOCIATED WITH NUCLEOLOGENESIS [J].
PAI, CY ;
CHEN, HK ;
SHEU, HL ;
YEH, NH .
JOURNAL OF CELL SCIENCE, 1995, 108 :1911-1920
[32]   Disruption of the actin cytoskeleton leads to inhibition of mitogen-induced cyclin E expression, cdk2 phosphorylation, and nuclear accumulation of the retinoblastoma protein-related p107 protein [J].
Reshetnikova, G ;
Barkan, R ;
Popov, B ;
Nikolsky, N ;
Chang, LS .
EXPERIMENTAL CELL RESEARCH, 2000, 259 (01) :35-53
[33]   pRb2/p130 promotes radiation-induced cell death in the glioblastoma cell line HJC12 by p73 upregulation and Bcl-2 downregulation [J].
Bruna Pucci ;
Pier Paolo Claudio ;
Valeria Masciullo ;
Lorenza Bellincampi ;
Alessandro Terrinoni ;
Kamel Khalili ;
Gerry Melino ;
Antonio Giordano .
Oncogene, 2002, 21 :5897-5905
[34]   pRb2/p130 promotes radiation-induced cell death in the glioblastoma cell line HJC12 by p73 upregulation and Bcl-2 downregulation [J].
Pucci, B ;
Claudio, PP ;
Masciullo, V ;
Bellincampi, L ;
Terrinoni, A ;
Khalili, K ;
Melino, G ;
Giordano, A .
ONCOGENE, 2002, 21 (38) :5897-5905
[35]   CELL CYCLE-SPECIFIC ASSOCIATION OF E2F WITH THE P130 E1A-BINDING PROTEIN [J].
COBRINIK, D ;
WHYTE, P ;
PEEPER, DS ;
JACKS, T ;
WEINBERG, RA .
GENES & DEVELOPMENT, 1993, 7 (12A) :2392-2404
[36]   A COMPLEX BETWEEN E2F AND THE PRB-RELATED PROTEIN P130 IS SPECIFICALLY TARGETED BY THE SIMIAN-VIRUS-40 LARGE T-ANTIGEN DURING CELL-TRANSFORMATION [J].
WOLF, DA ;
HERMEKING, H ;
ALBERT, T ;
HERZINGER, T ;
KIND, P ;
EICK, D .
ONCOGENE, 1995, 10 (11) :2067-2078
[37]   THE RB2/P130 GENE-PRODUCT IS A NUCLEAR-PROTEIN WHOSE PHOSPHORYLATION IS CELL-CYCLE-REGULATED [J].
BALDI, A ;
DELUCA, A ;
CLAUDIO, PP ;
BALDI, F ;
GIORDANO, GG ;
TOMMASINO, M ;
PAGGI, MG ;
GIORDANO, A .
JOURNAL OF CELLULAR BIOCHEMISTRY, 1995, 59 (03) :402-408
[38]   Molecular alchemy of the tumor suppressor protein p53:: Metals and cell growth control [J].
Méplan, C ;
Hainaut, P .
JOURNAL OF TRACE ELEMENTS IN EXPERIMENTAL MEDICINE, 1999, 12 (04) :337-346
[39]   p202, an interferon-inducible negative regulator of cell growth, is a target of the adenovirus E1A protein [J].
Hong Xin ;
Sanjay D'Souza ;
Lei Fang ;
Peter Lengyel ;
Divaker Choubey .
Oncogene, 2001, 20 :6828-6839
[40]   p202, an interferon-inducible negative regulator of cell growth, is a target of the adenovirus E1A protein [J].
Xin, H ;
D'Souza, S ;
Fang, L ;
Lengyel, P ;
Choubey, D .
ONCOGENE, 2001, 20 (47) :6828-6839