Investigation of antimicrobial susceptibility, class i and II integrons among Pseudomonas aeruginosa isolates from hospitalized patients in Isfahan, Iran

被引：32
作者：
Faghri J. [1 ]
Nouri S. [2 ]
Jalalifar S. [1 ]
Zalipoor M. [1 ]
Halaji M. [3 ]
机构：
[1] Department of Microbiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan
[2] Department of Microbiology, Clinical Laboratory of ALZAHRA Medical Center, Isfahan
[3] Students Research Committee, Isfahan University of Medical Sciences, Hezar Jarib St, Isfahan
来源：
BMC Research Notes | / 11卷 / 1期
关键词：
Antibiotic resistance; Integrons; Pseudomonas aeruginosa;
D O I：
10.1186/s13104-018-3901-9
中图分类号：
学科分类号：
摘要：
Objectives: The role of integrons in the transfer of antibiotic resistance is one of the important issues, therefore, this study is aimed to investigate antibiotic resistance pattern and prevalence of class 1 and 2 integrons in P. aeruginosa isolated. Results: Out of 72 confirmed P. aeruginosa isolates, 50% were from ICU patients. Antibacterial susceptibility pattern showed that isolates were most resistant to ceftazidime (76.4%) and colistin was the most effective antibiotic (100%) and molecular analysis of class I and II integrons showed 55.5% and 29.1% of isolates were positive, respectively and the proportions of MDR isolates were significantly higher among integron-positive isolates with 73.6% compared to negative isolates with 22.9%. Our results showed that there was a correlation among class 1 and 2 integrons with MDR P. aeruginosa isolates. According to the importance of integrons in acquisition and dissemination of antibiotics resistance genes, the performance of antibiotic surveillance programs and investigating the role of integrons is recommended to control the spreading of antibiotics resistance genes. © 2018 The Author(s).
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  • [1] Sadikot R.T., Blackwell T.S., Christman J.W., Prince A.S., Pathogen-host interactions in Pseudomonas aeruginosa pneumonia, Am J Respir Crit Care Med, 171, pp. 1209-1223, (2005)
  • [2] Goldberg J.B., Why is Pseudomonas aeruginosa a pathogen?, F1000 Biol Rep, 2, (2010)
  • [3] Rada B., Interactions between neutrophils and Pseudomonas aeruginosa in cystic fibrosis, Pathogens, 6, (2017)
  • [4] Hirsch E.B., Impact of multidrug-resistant Pseudomonas aeruginosa infection on patient outcomes, Expert Rev Pharmacoecon Outcomes Res, 10, pp. 441-451, (2010)
  • [5] Aloush V., Navon-Venezia S., Seigman-Igra Y., Cabili S., Carmeli Y., Multidrug-resistant Pseudomonas aeruginosa: Risk factors and clinical impact, Antimicrob Agents Chemother, 50, pp. 43-48, (2006)
  • [6] Bennett P.M., Plasmid encoded antibiotic resistance: Acquisition and transfer of antibiotic resistance genes in bacteria, Br J Pharmacol, 153, pp. S347-S357, (2008)
  • [7] Gillings M.R., Integrons: Past, present, and future, Microbiol Mol Biol Rev, 78, pp. 257-277, (2014)
  • [8] Deng Y., Bao X., Ji L., Chen L., Liu J., Miao J., Et al., Resistance integrons: Class 1, 2 and 3 integrons, Ann Clin Microbiol Antimicrob, 14, (2015)
  • [9] Hansson K., Sundstrom L., Pelletier A., Roy P.H., IntI2 integron integrase in Tn7, J Bacteriol, 184, pp. 1712-1721, (2002)
  • [10] Hall R.M., Collis C.M., Antibiotic resistance in gram-negative bacteria: The role of gene cassettes and integrons, Drug Resist Updates, 1, pp. 109-119, (1998)
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