Soybean isoflavone ameliorates cognitive impairment, neuroinflammation, and amyloid β accumulation in a rat model of Alzheimer’s disease

被引：0
作者：
Amina E. Essawy
Heba Mohamed Abdou
Hania M. Ibrahim
Najya M. Bouthahab
机构：
[1] Alexandria University,Department of Zoology, Faculty of Science
[2] Omar Al Mukhtar University,Department of Zoology, Faculty of Science
来源：
Environmental Science and Pollution Research | 2019年 / 26卷
关键词：
Alzheimer’s disease; Colchicine; Soybean isoflavone; Rat;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Oxidative stress and neuroinflammatory changes appear to be the early events involved in AD’s development and progression. The present study was designed to assess the effect of soybean isoflavone extract (SIFE) against colchicine-induced cognitive dysfunction and oxidative stress in male rats.
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页码：26060 / 26070
页数：10
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[1]  
Aras AB(2015)Genistein exerts neuroprotective effect on focal cerebral ischemia injury in rats Inflammation 38 1311-1321
[2]  
Guven M(2013)Toxic effects of fluoride and chlorpyrifos on antioxidant parameters in rats: protective effects of vitamins C and E Fluoride 46 73-79
[3]  
Akman T(2016)Protective effect of epigallocatechin-3-gallate (EGCG) the major tea polyphenolic, against intracerebroventricularly colchicine induced oxidative damage production in brain and cognitive dysfunction in mice Alzheimer’s Dis Parkinsonism 6 2161-0460
[4]  
Alacam H(2013)Amyloid beta1-40-induced astrogliosis and the effect of genistein treatment in rat: a three-dimensional confocal morphometric and proteomic study PLoS One 8 1-14
[5]  
Kalkan Y(2017)Attenuation of neurobehavioral and neurochemical abnormalities in animal model of cognitive deficits of Alzheimer‘s disease by fermented soybean nanonutraceutical Inflammopharmacology 26 1-14
[6]  
Silan C(2013)Decreased astrocytic GFAP expression in streptozotocin-induced diabetes after gliotoxic lesion in the rat brainstem Arq Bras Endocrinol Metabol 57 431-436
[7]  
Cosar M(2013)Glutathione peroxidases Biochim Biophys Acta Gen Subj 1830 3289-3303
[8]  
Baba NA(2014)Doenjang, a Korean fermented soy food, exerts antiobesity and antioxidative activities in overweight subjects with the PPAR-γ2 C1431T polymorphism: 12-week, double-blind randomized clinical trial Med Food 17 119-127
[9]  
Raina R(1976)Purification and properties of rat lung soluble glutathione peroxidase Biochim Biophys Acta Enzymol 445 558-566
[10]  
Verma PK(2017)Molecular and therapeutic targets of genistein in Alzheimer’s disease Mol Neurobiol 54 7028-7041
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