The structure and mechanism of the Mycobacterium tuberculosis cyclodityrosine synthetase

被引：0
作者：
Matthew W Vetting
Subray S Hegde
John S Blanchard
机构：
[1] Albert Einstein College of Medicine,Department of Biochemistry
来源：
Nature Chemical Biology | 2010年 / 6卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Some cyclodipeptides are unusual in that their cyclic scaffold is created from activated, amino-acid–loaded tRNA substrates. Structural and biochemical evidence now demonstrates that the enzymes that perform this reaction are homologous to tRNA synthetases and use a covalently bound intermediate.[graphic not available: see fulltext]
引用
收藏
页码：797 / 799
页数：2
相关论文
共 50 条
  • [41] Optimization of Inhibitors of Mycobacterium tuberculosis Pantothenate Synthetase Based on Group Efficiency Analysis
    Hung, Alvin W.
    Silvestre, H. Leonardo
    Wen, Shijun
    George, Guillaume P. C.
    Boland, Jennifer
    Blundell, Tom L.
    Ciulli, Alessio
    Abell, Chris
    CHEMMEDCHEM, 2016, 11 (01) : 38 - 42
  • [42] Unearthing phytochemicals as natural inhibitors for pantothenate synthetase in Mycobacterium tuberculosis: A computational approach
    Chouhan, Mandeep
    Tiwari, Prashant Kumar
    Mishra, Richa
    Gupta, Saurabh
    Kumar, Mukesh
    Almuqri, Eman Abdullah
    Ibrahim, Nasir A.
    Basher, Nosiba Suliman
    Chaudhary, Anis Ahmad
    Dwivedi, Vivek Dhar
    Verma, Devvret
    Kumar, Sanjay
    FRONTIERS IN PHARMACOLOGY, 2024, 15
  • [43] Virtual screening to identify novel potential inhibitors for Glutamine synthetase of Mycobacterium tuberculosis
    Kumari, Madhulata
    Subbarao, Naidu
    JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2020, 38 (17) : 5062 - 5080
  • [44] Heterologous expression, purification, and enzymatic activity of Mycobacterium tuberculosis NAD+ synthetase
    Bellinzoni, M
    De Rossi, E
    Branzoni, M
    Milano, A
    Peverali, FA
    Rizzi, M
    Riccardi, G
    PROTEIN EXPRESSION AND PURIFICATION, 2002, 25 (03) : 547 - 557
  • [45] The MTCY428.08 gene of Mycobacterium tuberculosis codes for NAD+ synthetase
    Cantoni, R
    Branzoni, M
    Labò, M
    Rizzi, M
    Riccardi, G
    JOURNAL OF BACTERIOLOGY, 1998, 180 (12) : 3218 - 3221
  • [46] Mutational analysis of the (p)ppGpp synthetase activity of the Rel enzyme of Mycobacterium tuberculosis
    Bag, Satyabrata
    Das, Bhabatosh
    Dasgupta, Shreya
    Bhadra, Rupak K.
    ARCHIVES OF MICROBIOLOGY, 2014, 196 (08) : 575 - 588
  • [47] Structure of Mycobacterium tuberculosis PknB supports a universal activation mechanism for Ser/Thr protein kinases
    Tracy A. Young
    Benedicte Delagoutte
    James A. Endrizzi
    Arnold M. Falick
    Tom Alber
    Nature Structural & Molecular Biology, 2003, 10 : 168 - 174
  • [48] Structure of Mycobacterium tuberculosis phosphatidylinositol phosphate synthase reveals mechanism of substrate binding and metal catalysis
    Kristīne Grāve
    Matthew D. Bennett
    Martin Högbom
    Communications Biology, 2
  • [49] Structure of Mycobacterium tuberculosis phosphatidylinositol phosphate synthase reveals mechanism of substrate binding and metal catalysis
    Grave, Kristine
    Bennett, Matthew D.
    Hogbom, Martin
    COMMUNICATIONS BIOLOGY, 2019, 2 (1)
  • [50] The crystal structure of Mycobacterium tuberculosis high-temperature requirement A protein reveals an autoregulatory mechanism
    Gupta, Arvind Kumar
    Behera, Debashree
    Gopal, Balasubramanian
    ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 2018, 74 : 803 - 809
12345