Adoptive transfer of genetically engineered WT1-specific cytotoxic T lymphocytes does not induce renal injury

被引：0

作者：

Hiroaki Asai

Hiroshi Fujiwara

Sohei Kitazawa

Naoto Kobayashi

Toshiki Ochi

Yukihiro Miyazaki

Fumihiro Ochi

Yoshiki Akatsuka

Sachiko Okamoto

Junichi Mineno

Kiyotaka Kuzushima

Hiroaki Ikeda

Hiroshi Shiku

Masaki Yasukawa

机构：

[1] Clinical Immunology,Department of Hematology

[2] and Infectious Diseases,Department of Molecular Pathology

[3] Ehime University Graduate School of Medicine,Medical Education Center

[4] Ehime University Graduate School of Medicine,Department of Hematology and Oncology

[5] Ehime University Graduate School of Medicine,Center for Cell and Gene Therapy

[6] Fujita Health University,Division of Immunology

[7] Takara Bio Inc.,Department of Immuno

[8] Aichi Cancer Center Research Institute,Gene Therapy

[9] Mie University Graduate School of Medicine,undefined

来源：

Journal of Hematology & Oncology | / 7卷

关键词：

Immunotherapy; WT1; Podocytes; Cytotoxic T lymphocytes;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Because WT1 is expressed in leukemia cells, the development of cancer immunotherapy targeting WT1 has been an attractive translational research topic. However, concern of this therapy still remains, since WT1 is abundantly expressed in renal glomerular podocytes. In the present study, we clearly showed that WT1-specific cytotoxic T lymphocytes (CTLs) certainly exerted cytotoxicity against podocytes in vitro; however, they did not damage podocytes in vivo. This might be due to the anatomical localization of podocytes, being structurally separated from circulating CTLs in glomerular capillaries by an exceptionally thick basement membrane.

引用

共 90 条

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