Crystal structure of the Src family tyrosine kinase Hck

被引：0
作者：
Frank Sicheri
Ismail Moarefi
John Kuriyan
机构：
[1] The Rockefeller University,Laboratories of Molecular Biophysics
[2] The Rockefeller University,Howard Hughes Medical Institute
来源：
Nature | 1997年 / 385卷
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摘要：
The crystal structure of the haematopoietic cell kinase Hck has been determined at 2.6/2.9 Å resolution. Inhibition of enzymatic activity is a consequence of intramolecular interactions of the enzyme's Src-homology domains SH2 and SH3, with concomitant displacement of elements of the catalytic domain. The conformation of the active site has similarities with that of inactive cyclin-dependent protein kinases.
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页码：602 / 609
页数：7
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