Synthesis and analgesic activity of 1-aryl-3-aroyl-4-hydroxy-5',5'-dimethyl-8',9'-diethoxy-5',6'-dihydro-3'h-spiro{pyrrole-2,2'-pyrrolo[2,1-a]isoquinoline}-3',5(1H )-diones

被引：0
|
作者：
E. S. Denislamova
Yu. V. Shklyaev
R. R. Makhmudov
A. N. Maslivets
机构：
[1] Perm State University,Institute of Natural Sciences
[2] Russian Academy of Sciences,Institute of Technical Chemistry, Ural Branch
[3] Perm State University,undefined
来源：
Pharmaceutical Chemistry Journal | 2012年 / 46卷
关键词：
1; -pyrrole-2,3-diones; 1-methyl-3,4-dihydroisoquinolines; analgesic activity;
D O I：
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中图分类号：
学科分类号：
摘要：
1-Aryl-4-aroyl-5-methoxycarbonyl-1H-pyrrole-2,3-diones reacted with 6,7-diethoxy-1,3,3-trimethyl-3,4-dihydroisoquinoline with the formation of 1-aryl-3-aroyl-4-hydroxy-5',5'-dimethyl-8',9'-diethoxy-5',6'-dihydro-3'H-spiro{pyrrole-2,2'-pyrrolo[2,1-a]isoquinoline}-3',5(1H)-diones. The synthesized compounds exhibited analgesic activity.
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页码：551 / 552
页数：1
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