Phase II study of chemotherapy with ACNU plus cisplatin followed by cranial irradiation in patients with newly diagnosed glioblastoma multiforme

被引：0

作者：

Sil Choi I. ^{[1
]}

Hoon Lee S. ^{[1
]}

Kim T.-Y. ^{[1
]}

Seug Bang J. ^{[2
]}

Ha Paek S. ^{[2
]}

Kim S. ^{[3
]}

Han Kim I. ^{[4
]}

Seog Heo D. ^{[1
]}

Bang Y.-J. ^{[1
]}

Gyu Kim D. ^{[2
]}

Jung H.-W. ^{[2
]}

Kyeong Kim N. ^{[1
]}

机构：

[1] Department of Internal Medicine, Seoul National University, College of Medicine, Seoul

[2] Department of Neurosurgery, Seoul National University, College of Medicine, Seoul

[3] Department of Therapeutic Radiology, Seoul National University, College of Medicine, Seoul

[4] Department of Therapeutic Radiology, Cancer Research Institute, Seoul National University College of Medicine, Seoul

来源：

Journal of Neuro-Oncology | 2002年 / 60卷 / 2期

关键词：

Chemotherapy; Glioblastoma; Phase II trial; Radiotherapy;

D O I：

10.1023/A:1020605617452

中图分类号：

学科分类号：

摘要：

Purpose: To evaluate the efficacy and toxicity of chemotherapy with ACNU (1-(4-amino-2-methyl-5-pyrimidinyl)-methyl-(2-chloroethyl)-3-nitrosourea) plus cisplatin followed by cranial irradiation in patients with newly diagnosed glioblastoma multiforme. Patients and methods: Between August 1999 and July 2001, previously untreated 30 patients with histologically confirmed glioblastoma multiforme were treated. Chemotherapy consisting of up to 2 cycles of 72 h of continuous intravenous infusion of ACNU (40 mg/m2/day) and cisplatin (40 mg/m2/d) was given over a 6-week period. Radiation was begun 6 weeks after the second cycle of chemotherapy. Results: Median age was 48 years (range 18-66 years) and 22 patients with residual measurable disease after surgery were eligible for response analysis. One (5%) had a complete response (CR), 36% partial response (PR), 14% stable disease (SD), and 45% progressive disease (PD) after chemotherapy. After additional radiation, 22% had CR, 22% PR, 16% SD, and 42% PD. Grades III and IV leukopenia and thrombocytopenia occurred in 18 cycles (36%) and 15 cycles (30%), respectively. No fatal complications occurred. Median time to progression was 5.9 months (95% CI 5.1-6.8 months) and median overall survival was 14.9 months (95% CI 9.1-20.7 months). Conclusions: Preradiation chemotherapy with ACNU plus cisplatin is effective and feasible in patients with glioblastoma multiforme.

引用

页码：171 / 176

页数：5

共 19 条

[1]

Lesser G.J., Grossman S., The chemotherapy of high-grade astrocytoma, Semin Oncol, 21, pp. 220-235, (1994)

[2]

Vecht C.J., Avezaat C.J.J., Van Putten W.L.J., The influence of the extent of surgery on the neurological function and survival in malignant glioma. A retrospective analysis in 243 patients, J Neurosurg Neuropsych, 53, pp. 466-471, (1999)

[3]

Salazar O.M., Rubin P., The spread of glioblastoma as a determining factor in the radiation treated volume, Int J Radiat Oncol Biol Phys, 1, pp. 627-637, (1996)

[4]

Burger P.C., Heinz E.R., Shibata T., Kleihues P., Topographic anatomy and CT correlations in the untreated glioblastoma multiforme, J Neurosurg, 68, pp. 698-704, (1998)

[5]

Walker M.D., Green S.B., Byar D.P., Randomized comparison of radiotherapy and nitrosoureas for the treatment of malignant glioma after surgery, New Engl J Med, 303, 23, pp. 1323-1329, (1980)

[6]

Bamberg M., Hess C.F., Radiation therapy of malignant gliomas, Onkologie, 15, pp. 178-189, (1992)

[7]

Kristiansen K., Hagen S., Kollwvoid T., Combined modality therapy of operated astrocytomas grade III and IV. Confirmation of the value of postoperative irradiation and lack of potentiation of bleomycin on survival time: A prospective multicenter trial of the Scandinavian glioblastoma study group, Cancer, 47, pp. 649-652, (1981)

[8]

Fine H.A., Dear K.B.G., Loeffler J.S., Black P.M.L., Canellos G., Meta-analysis of radiation therapy with or without adjuvant chemotherapy for malignant gliomas in adults, Cancer, 71, pp. 2585-2597, (1993)

[9]

Greenburg H.S., Ensminger W.D., Chandler W.F., Intraarterial BCNU chemotherapy in the treatment of malignant gliomas of the central nervous system, J Neurosurg, 61, pp. 423-429, (1984)

[10]

Duffner P.K., Horowitz M.E., Krischer J.P., Friedman H.S., Burger P.C., Cohen M.E., Sanford R.A., Mulhern R.K., James H.E., Freeman C.R., Seidel F.G., Kun L.E., Post-operative chemotherapy and delayed radiation in children less than three years of age with malignant brain tumors, N Engl J Med, 328, pp. 1725-1731, (1993)

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