Prognostic relevance of in expression in breast cancer

被引：16

作者：

Tsuchiya A. ^{[1
]}

Kanno M. ^{[1
]}

Kawaguchi T. ^{[2
]}

Endo Y. ^{[1
]}

Zhang G.-J. ^{[1
]}

Ohtake T. ^{[1
]}

Kimijima I. ^{[1
]}

机构：

[1] Department of Surgery II, Fukushima Medical University, School of Medicine, 1, Hikarigaoka

[2] Department of Patholog II, Fukushima Medical University, School of Medicine, 1, Hikarigaoka

来源：

Breast Cancer | 1999年 / 6卷 / 3期

关键词：

Breast cancer; Mucin; Survival; Tn antigen;

D O I：

10.1007/BF02967164

中图分类号：

学科分类号：

摘要：

Background: Abnormal glycosylation patterns have been recognized as a feature of carcinomaassociated mucins. The expression of the Tn antigen in breast cancer tissue was investigated to assess its prognostic relevance. Methods: Formalin-fixed, paraffin-embedded materials from 219 patients with breast cancer were used. Immunohistochemical staining of the Tn antigen was retrospectively investigated and a lesion staining 10% or more was considered positive. Results: Tn antigen expression was present in 99 (45%) of 219 lesions. There were no correlations between Tn antigen expression and mean patient age, nodal status, estrogen receptor status, or menopausal status, but there was a slightly significant association between Tn and tumor size. Patients negative for the Tn antigen had a significantly better survival rate than those who were positive. Multivariate analysis also indicated that Tn expression correlated significantly with overall survival in addition to nodal status and tumor size. Conclusions: Tn expression was a significant prognostic factor in breast cancer, but the significance was lost on multivariate analysis. The biological implication of Tn expression in breast cancer needs further investigation.

引用

页码：175 / 180

页数：5

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