Osteoradionecrosis of the jaws-a current overview-part 2: Dental management and therapeutic options for treatment

被引：47
作者：
Chrcanovic B.R. [1 ]
Reher P. [2 ,3 ]
Sousa A.A. [4 ,5 ]
Harris M. [6 ]
机构：
[1] Belo Horizonte, MG-CEP 30441-070, Av. Raja Gabaglia
[2] School of Dentistry and Oral Health, Gold Coast Campus, Griffith University, Southport, QLD 4215
[3] Department of Oral and Maxillofacial Surgery, School of Dentistry, Pontifícia Universidade Católica de Minas Gerais, Belo Horizonte 30535-610 Minas Gerais, Av. Dom José Gaspar
[4] Hospital das Clínicas UFMG, Instituto Alfa de Gastroenterologia, Head and Neck Surgery, Belo Horizonte, Minas Gerais 30130-100, Av. Prof Alfredo Balena 110, Santa Efigênia
[5] Belo Horizonte, Minas Gerais 30110-060, Rua Contorno 5351/1202, Cruzeiro
[6] Oral and Maxillofacial Surgery, Eastman Dental Institute, University College London, London, WC1X 8LD
来源：
Oral and Maxillofacial Surgery | 2010年 / 14卷 / 2期
关键词：
Dental care; Jaw; Osteoradionecrosis; Treatment;
D O I：
10.1007/s10006-010-0205-1
中图分类号：
学科分类号：
摘要：
Purpose: The aim of this paper is to explore the current theories about pretreatment assessment and dental management of patients receiving head and neck radiotherapy, and the therapeutic options to treat osteoradionecrosis of the jaws, based on the literature review. Discussion: Osteoradionecrosis is one of the most serious oral complications of head and neck cancer treatment. Osteoradionecrosis is a severe delayed radiation-induced injury, characterized by bone tissue necrosis and failure to heal. Osteoradionecrosis either stabilizes or gradually worsens and is notoriously difficult to manage. Because most cases occur in patients who were dentulous in the mandible at tumor onset, proper dental management is the single most important factor in prevention. Conclusions: Complete dental clearance before treatment is no longer necessary. Controversy exists regarding the management of osteoradionecrosis of the maxillofacial skeleton because of the variability of this condition. The treatment of osteoradionecrosis has included local wound care, antibiotic therapy, surgical procedures, and the administration of hyperbaric oxygenation. Recently, new methods of treatment were introduced, according to the new theory about its pathophysiology. © 2010 Springer-Verlag.
引用
收藏
页码：81 / 95
页数：14
相关论文
共 121 条
[71]  
Hansen T., Kunkel M., Kirkpatrick C.J., Weber A., Actinomyces in infected osteoradionecrosis-underestimated?, Hum Pathol, 37, pp. 61-67, (2006)
[72]  
Annane D., Depondt J., Aubert P., Villart M., Gehanno P., Gajdos P., Chevret S., Hyperbaric oxygen therapy for radionecrosis of the jaw: A randomized, placebo-controlled, double-blind trial from the ORN96 study group, J Clin Oncol, 22, pp. 4893-4900, (2004)
[73]  
Goaz P.W., White S.C., Infections and inflammations of the jaws and facial bones, Oral Radiology: Principles and Interpretation, pp. 381-397, (1994)
[74]  
Galler C., Epstein J.B., Guze K.A., Buckles D., Stevenson-Moore P., The development of osteoradionecrosis from sites of periodontal disease activity: Report of 3 cases, J Periodontol, 63, pp. 310-316, (1992)
[75]  
Epstein J.B., Lunn R., Le N., Stevenson-Moore P., Periodontal attachment loss in patients after head and neck radiation therapy, Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 866, pp. 673-677, (1998)
[76]  
Moller P., Perrier M., Ozsahin M., Monnier P., A prospective study of salivary gland function in patients undergoing radiotherapy for squamous cell carcinoma of the oropharynx, Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 972, pp. 173-189, (2004)
[77]  
Scully C., Porter S., Oral cancer, West J Med, 174, pp. 348-351, (2001)
[78]  
Wong J.K., Wood R.E., McLean M., Conservative management of osteoradionecrosis, Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 84, pp. 16-21, (1997)
[79]  
van Merkesteyn J.P.R., Bakker D.J., Borgmeijer-Hoelen A.M.M.J., Hyperbaric oxygen treatment of osteoradionecrosis of the mandible: Experience in 29 patients, Oral Surg Oral Med Oral Patho1 Oral Radiol Endod, 80, pp. 12-16, (1995)
[80]  
Mainous E.G., Boyne P.J., Hart G.B., Elimination of sequestrum and healing of osteoradionecrosis of the mandible after hyperbaric oxygen therapy: Report of case, J Oral Surg, 31, pp. 336-339, (1973)
3456789101112