BH3-only proteins in apoptosis and beyond: an overview

被引：0
作者：
E Lomonosova
G Chinnadurai
机构：
[1] Institute for Molecular Virology,
[2] Saint Louis University School of Medicine,undefined
[3] Doisy Research Center,undefined
[4] 2Current address: Department of Molecular Microbiology and Immunology,undefined
[5] Saint Louis University School of Medicine,undefined
来源：
Oncogene | 2008年 / 27卷
关键词：
BH3-only; apoptosis; autophagy; non-apoptotic functions; cancer;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
BH3-only BCL-2 family proteins are effectors of canonical mitochondrial apoptosis. They discharge their pro-apoptotic functions through BH1–3 pro-apoptotic proteins such as BAX and BAK, while their activity is suppressed by BH1–4 anti-apoptotic BCL-2 family members. The precise mechanism by which BH3-only proteins mediate apoptosis remains unresolved. The existing data are consistent with three mutually non-exclusive models (1) displacement of BH1–3 proteins from complexes with BH1–4 proteins; (2) direct interaction with and conformational activation of BH1–3 proteins; and (3) membrane insertion and membrane remodeling. The BH3-only proteins appear to play critical roles in restraining cancer and inflammatory diseases such as rheumatoid arthritis. Molecules that mimic the effect of BH3-only proteins are being used in treatments against these diseases. The cell death activity of a subclass of BH3-only members (BNIP3 and BNIP3L) is linked to cardiomyocyte loss during heart failure. In addition to their established role in apoptosis, several BH3-only members also regulate diverse cellular functions in cell-cycle regulation, DNA repair and metabolism. Several members are implicated in the induction of autophagy and autophagic cell death, possibly through unleashing of the BH3-only autophagic effector Beclin 1 from complexes with BCL-2/BCL-xL. The Chapters included in the current Oncogene Review issues provide in-depth discussions on various aspects of major BH3-only proteins.
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页码：S2 / S19
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