Anti-cardiolipin and Anti-β2-glycoprotein I Antibodies in Patients with Inflammatory Bowel Disease

被引：0
作者：
I. E. Koutroubakis
E. Petinaki
E. Anagnostopoulou
H. Kritikos
I. A. Mouzas
E. A. Kouroumalis
O. N. Manousos
机构：
来源：
Digestive Diseases and Sciences | 1998年 / 43卷
关键词：
ANTI-CARDIOLIPIN; ANTIBODIES; ANTI-β; -GLYCOPROTEIN I; CROHN'S DISEASE; THROMBOSIS; PHOSPHOLIPID-BINDING ANTIBODIES; ULCERATIVE COLITIS;
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摘要：
Patients with inflammatory bowel disease (IBD)frequently suffer from thromboembolic events.Anti-cardiolipin (aCL) antibodies have been shown to beassociated with thrombosis. Recently, the antibodies against the anti-cardiolipin cofactorβ2-glycoprotein I(aβ2GPI) have been found with higherspecificity for thrombosis. The presence of theseantibodies was assessed in 128 patients with IBD [83 with ulcerative colitis (UC) and 45 withCrohn's disease (CD)] and 100 healthy controls (blooddonors). Patients with UC and CD had a significantlyhigher prevalence of aCL (18.1% and 15.6%, respectively) than healthy controls (HC) (3%). Eleven IBDpatients (8.6%) but no HC had aβ2GPI.None of the IBD patients with a history of thrombosishad aCL and only one of them (a UC patient with deepvein thrombosis of the right leg) had a high titer of IgGaβ2GPI. In conclusion, these data showthat both aCL and aβ2GPI aresignificantly associated with IBD but further studiesare needed to determine the significance of our findings.
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页码：2507 / 2512
页数：5
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