A convenient approach to the synthesis of 1-halomethyl-substituted 2,4,5,6-tetrahydro-1H-imidazo[1,2-a][1]benzazepines

被引：0
作者：
Ivanna Yu. Danyliuk
Valentyna S. Tolmachova
Eduard B. Rusanov
Mikhailo V. Vovk
机构：
[1] Institute of Organic Chemistry,
[2] National Academy of Sciences of Ukraine,undefined
[3] National Pedagogical Dragomanov University,undefined
来源：
Chemistry of Heterocyclic Compounds | 2021年 / 57卷
关键词：
-allyl-4,5-dihydro-3; -1-benzazepin-2-amines; benzazepines; 1-(halomethyl)-2,4,5,6-tetrahydro-1; -imidazo[1,2-; ][1]benzazepines; 2-methoxy-4,5-dihydro-3; -1-benzazepinones; electrophilic cyclization;
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摘要：
Intramolecular halocyclization of N-allyl-4,5-dihydro-3H-1-benzazepin-2-amines, obtained by consecutive methylation and allylamination of benzazepin-2-ones, by the action of N-iodo(bromo)succinimide in acetonitrile at room temperature lead to the formation 1-(iodo(bromo)methyl)-2,4,5,6-tetrahydro-1H-imidazo[1,2-a][1]benzazepines in high yields.
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页码：1187 / 1194
页数：7
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