Role of nitric oxide in the stress-induced release of serotonin in the locus coeruleus

被引：0
|
作者：
Catrin Sinner
Stefan T. Kaehler
Athineos Philippu
Nicolas Singewald
机构：
[1] Department of Pharmacology and Toxicology,
[2] University of Innsbruck,undefined
[3] Peter-Mayr-Strasse 1,undefined
[4] 6020 Innsbruck,undefined
[5] Austria,undefined
来源：
Naunyn-Schmiedeberg's Archives of Pharmacology | 2001年 / 364卷
关键词：
Locus coeruleus Serotonin Nitric oxide NO donor L-NAME Noise stress Tail pinch Push-pull superfusion;
D O I：
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学科分类号：
摘要：
Serotonergic mechanisms within the locus coeruleus (LC) are thought to be important in various functions including the stress response. In this study we investigated a possible role of nitric oxide (NO) as an intermediary messenger in the regulation of the serotonin (5-HT) neurotransmission within the LC. Using the push-pull superfusion technique coupled with HPLC and electrochemical detection, the in vivo release of 5-HT was determined in time periods of 10 min in the LC of freely moving rats.
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页码：105 / 109
页数：4
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